Protein Arginine Deiminase
Peptidylarginine Deiminase
Protein arginine deiminase (PAD), is a group of calcium-dependent enzymes, which play crucial roles in citrullination, and can catalyze arginine residues into citrulline. his chemical reaction induces citrullinated proteins formation with altered structure and function, leading to numerous pathological diseases, including inflammation and autoimmune diseases. These pathologies established the PADs as therapeutic targets and multiple PAD inhibitors are known.
Humans encode five PADs, designated PADs 1-4 and PAD6. Of the five PAD isozymes (PAD1, 2, 3, 4 and 6), only four (PADs1-4) are catalytically active. PAD activity is tightly regulated by Ca2+ and PADs contain 4 (PAD1), 5 (PAD3, 4) or 6 (PAD2) Ca2+-binding sites. Dysregulated PAD activity, most notably PAD2 and PAD4, is associated with multiple inflammatory diseases (e.g., rheumatoid arthritis) as well as cancer, and PAD inhibitors, such as Cl-amidine and BB-Cl-amidine, show efficacy in multiple preclinical animal models of disease.
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Protein Arginine Deiminase Related Products (66)
Related Products (66)
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F-Amidine
0 ImagesCat. No.: HY-126560CAS No.: 877617-45-3F-Amidine is a Protein arginine deiminase 4 (PAD4) inhibitor. F-Amidine can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis).
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Acefylline piperazine
0 ImagesCat. No.: HY-B1505ACAS No.: 18833-13-1Synonyms: Theophyllineacetic acid piperazine; Theophylline-7-acetic acid piperazineAcefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research.
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Hydroquinine (Standard)
0 ImagesHydroquinine (Standard) is the analytical standard of Hydroquinine. Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride.
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GSK199 analog hydrochloride
0 ImagesCat. No.: HY-115676CAS No.: 2048226-46-4GSK199 analog hydrochloride belongs to a class of compounds that inhibit PAD4 (guanidinoarginine deiminase 4). GSK199 analog hydrochloride has potential uses in diseases including rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosus, and psoriasis.
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BB-Cl-Amidine hydrochloride (Standard)
0 ImagesCat. No.: HY-111347ARCAS No.: 2436747-41-8BB-Cl-Amidine hydrochloride (Standard) is the analytical standard of BB-Cl-Amidine (hydrochloride) (HY-111347A). This product is intended for research and analytical applications. BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.
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D-Cl-amidine hydrochloride (Standard)
0 ImagesCat. No.: HY-100574DRCAS No.: 2985338-61-0D-Cl-amidine (hydrochloride) (Standard) is the analytical standard of D-Cl-amidine (hydrochloride) (HY-100574D). This product is intended for research and analytical applications. D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.
