Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(629)
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Nav1.1
(12)
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Nav1.2
(17)
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Nav1.3
(15)
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Nav1.4
(15)
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Nav1.5
(27)
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Nav1.6
(13)
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Nav1.7
(63)
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Nav1.8
(42)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
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Sodium Channel Agonists
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Sodium Channel Antagonists
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Sodium Channel Activators
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Sodium Channel Modulators
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Sodium Channel Controls
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Sodium Channel Ligands
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Sodium Channel Related Products (810)
Related Products (810)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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5-(N,N-Hexamethylene)-amiloride (Standard)
0 ImagesSynonyms: Hexamethylene amiloride (Standard); HMA (Standard)5-(N,N-Hexamethylene)-amiloride (Standard) is the analytical standard of 5-(N,N-Hexamethylene)-amiloride. This product is intended for research and analytical applications. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.
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Flecainide hydrochloride (Standard)
0 ImagesCat. No.: HY-W010950ARCAS No.: 57415-44-8Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
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QX-314 bromide (Standard)
0 ImagesCat. No.: HY-101350RCAS No.: 24003-58-5QX-314 (bromide) (Standard) is the analytical standard of QX-314 (bromide) (HY-101350). This product is intended for research and analytical applications. QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
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BTS 39542
0 ImagesCat. No.: HY-126038CAS No.: 57410-31-8BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research.
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Co 102862 (Standard)
0 ImagesCat. No.: HY-108504RCAS No.: 181144-66-1Synonyms: V 102862 (Standard)
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Recainam (Standard)
0 ImagesCat. No.: HY-105454RCAS No.: 74738-24-2Synonyms: Wy-42362 (Standard)Recainam (Standard) is the analytical standard of Recainam. This product is intended for research and analytical applications. Recainam is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam can be used for the research of arrhythmias.
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NaV1.7 blocker-801
0 ImagesCat. No.: HY-116194CAS No.: 1235403-75-4NaV1.7 blocker-801 is a NaV1.7 channel blocker that can be used in the study of neurological diseases.
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Eslicarbazepine (Standard)
0 ImagesCat. No.: HY-114703RCAS No.: 104746-04-5Synonyms: BIA 2-194 (Standard)Eslicarbazepine (Standard) is the analytical standard of Eslicarbazepine. This product is intended for research and analytical applications. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
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Fluphenazine-d6 hydrochloride
0 ImagesCat. No.: HY-119980BSFluphenazine-d6 (hydrochloride) is deuterium labeled Fluphenazine (hydrochloride). Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
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PF-04885614 (Standard)
0 ImagesCat. No.: HY-110325RCAS No.: 1480833-70-2PF-04885614 (Standard) is the analytical standard of PF-04885614 (HY-110325). This product is intended for research and analytical applications. PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment.
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Nav1.7-IN-3 (Standard)
0 ImagesCat. No.: HY-101789RCAS No.: 1788872-06-9Nav1.7-IN-3 (Standard) is the analytical standard of Nav1.7-IN-3 (HY-101789). This product is intended for research and analytical applications. Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.
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Dibucaine hydrochloride (Standard)
0 ImagesSynonyms: Cinchocaine hydrochloride (Standard)Dibucaine (hydrochloride) (Standard) is the analytical standard of Dibucaine (hydrochloride). This product is intended for research and analytical applications. Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
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Ajmaline (Standard)
0 ImagesSynonyms: Cardiorythmine (Standard); (+)-Ajmaline (Standard)Ajmaline (Standard) is the analytical standard of Ajmaline. This product is intended for research and analytical applications. Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia.
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Amiloride-15N3
0 ImagesCat. No.: HY-B0285SCAS No.: 1217169-93-1Synonyms: MK-870-15N3Amiloride-15N3 (MK-870-15N3) is 15N labeled Amiloride. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
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Mexiletine-d6
0 ImagesCat. No.: HY-119521S1CAS No.: 1330267-50-9Synonyms: KOE-1173-d6Mexiletine-d6 (KOE-1173-d6) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research.
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Propafenone (Standard)
0 ImagesSynonyms: SA-79 (Standard)Propafenone (Standard) is the analytical standard of Propafenone. This product is intended for research and analytical applications. Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM). Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis.
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AM-2099 (Standard)
0 ImagesCat. No.: HY-100727RCAS No.: 1443373-17-8AM-2099 (Standard) is the analytical standard of AM-2099 (HY-100727). This product is intended for research and analytical applications. AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7.
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Metaflumizone-d4
0 ImagesCat. No.: HY-116448SMetaflumizone-d4 is deuterium labeled Metaflumizone. Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker.
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Flecainide acetate (Standard)
0 ImagesSynonyms: R-818 (Standard)Flecainide (acetate) (Standard) is the analytical standard of Flecainide (acetate). This product is intended for research and analytical applications. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
