57415-44-8
Chemical Structure
Flecainide hydrochloride
- CAS No.: 57415-44-8
- Formula:C17H21ClF6N2O3
- Molecular Weight:450.80
IUPAC Name: N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide hydrochloride
InChIKey: FPTQDMHWQWTIAX-UHFFFAOYSA-N
SMILES: O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.[H]Cl
Biological Activity: Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT)[1][2][3].
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Flecainide hydrochloride | 99.93% | Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). | ||||||||||||||||||||
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Flecainide hydrochloride (Standard) | ≥98% | Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). | ||||||||||||||||||||
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Similarity Score 0.99
HY-124883R-(–)-Flecainide -
Similarity Score 0.99
HY-W010950Flecainide -
Similarity Score 0.94
HY-17429Flecainide acetate -
Similarity Score 0.82
HY-Z8177Flecainide Impurity 2 -
Similarity Score 0.71
HY-17429SFlecainide-d4 acetate -
Similarity Score 0.67
HY-W010950SFlecainide-d3 -
Similarity Score 0.67
HY-Z8178Flecainide Impurity 3 -
Similarity Score 0.53
HY-112217APSEM 89S TFA -
Similarity Score 0.50
HY-160997Prosulpride -
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References
- [1]. Kuroda Y, et al. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochem Biophys Rep. 2017 Jan 11;9:245-256. [Content Brief]
- [2]. Watanabe H, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009 Apr;15(4):380-3.
