Syk
Spleen tyrosine kinase
Syk (Spleen tyrosine kinase) is a cytosolic non-receptor protein tyrosine kinase (PTK) that is expressed at high levels, both in hematopoietic cells (such as mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages) and in non-hematopoietic cells.
Syk mediates key signal transduction pathways following the activation of immune cell receptors. Syk associates with different receptors on the surface of various cells such as B cells, mast cells, monocytes, macrophages, and neutrophils, and even osteoclasts and breast cancer cells. Following the engagement of these receptors with their ligands, SYK is activated and orchestrates diverse cellular responses, including cytokine production (in T cells and monocytes) and phagocytosis (in macrophages).
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Syk Related Products (101)
Related Products (101)
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GSK143
0 ImagesCat. No.: HY-12736CAS No.: 1240390-27-5
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Gusacitinib-d4
0 ImagesCat. No.: HY-103018SSynonyms: ASN-002-d4Gusacitinib-d4 (ASN-002-d4) is the deuterium labeled Gusacitinib (HY-103018). Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma.
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Ibt-DOX
0 ImagesCat. No.: HY-181546Ibt-DOX is a BTK inhibitor with an IC50 of 2.89 nM. Ibt-DOX is also a targeted covalent activated chemotherapeutic agent composed of the targeting ligand Ibrutinib (HY-10997), Doxorubicin (DOX) (HY-15142A), α-MAA (HY-W017180), and a linker (HY-Y0892). Ibt-DOX specifically binds to BTK and releases DOX, synergistically achieving BTK inhibition and chemotherapeutic killing, significantly enhancing toxicity against B-cell lymphoma cells and greatly reducing the toxic side effects of DOX on BTK-negative cells. Ibt-DOX can be used in lymphoma-related research.
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Syk Kinase Peptide Substrate
0 ImagesCat. No.: HY-P2505CAS No.: 865778-47-8
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TAS05567
0 ImagesCat. No.: HY-120214CAS No.: 1429038-15-2TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases.
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SYK-IN-15
0 ImagesCat. No.: HY-184306SYK-IN-15 is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 10.9 nM. SYK-IN-15 induces cell cycle S-phase arrest and cell apoptosis. SYK-IN-15 inhibits cancer cell colony formation and exerts antiproliferative effects on cancer cells. SYK-IN-15 can be used for the research of solid tumors (ovarian cancer, breast cancer, liver cancer).
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Syk-IN-8
0 ImagesCat. No.: HY-155513CAS No.: 2568963-01-7Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers.
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TOP1362
0 ImagesCat. No.: HY-125500CAS No.: 1630203-25-6TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome.
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DBMB
0 ImagesCat. No.: HY-169630CAS No.: 314027-66-2DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.
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MK-8457
0 ImagesCat. No.: HY-112319ACAS No.: 1312518-85-6MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension.
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Syk-IN-16
0 ImagesCat. No.: HY-184655CAS No.: 3102293-90-0Syk-IN-16 is a spleen tyrosine kinase (SYK) inhibitor with an IC50 of 16.0 nM. Syk-IN-16 exerts antiproliferative effects, induces cell apoptosis, inhibits cell migration and increases DNA damage in cancer cells. Syk-IN-16 suppresses tumor growth in xenograft models without obvious toxicity. Syk-IN-16 can be used for the research of triple-negative breast cancer.
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BI 894416
0 ImagesCat. No.: HY-156196CAS No.: 1810059-82-5BI 894416 is a spleen tyrosine kinase (SYK) inhibitor. BI 894416 has a deuterium-labeled derivative that can be used as an internal standard for bioanalytical studies. BI 894416 is applicable to the research of severe asthma.
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Syk Inhibitor II dihydrochloride dihydrate
0 ImagesCat. No.: HY-112390BCAS No.: 1965323-05-0Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect.
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SYK/JAK-IN-1
0 ImagesCat. No.: HY-145029CAS No.: 2737326-28-0
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(rel)-PRT062607
0 ImagesCat. No.: HY-15322ACAS No.: 1194954-52-3Synonyms: (rel)-P505-15; (rel)-PRT-2607; (rel)-BIIB-057
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GT103
0 ImagesCat. No.: HY-P991954GT103 is a human-derived monoclonal antibody targeting complement factor H (CFH). GT103 binds to a conformationally distinct epitope of CFH on tumor cells. GT103 activates the classical complement pathway, induces complement-dependent cytotoxicity, and triggers antibody-dependent cellular phagocytosis (ADCP) of tumor cells. GT103 increases calreticulin translocation to tumor cell plasma membranes. GT103 mediates B-cell activation via Syk kinase phosphorylation. GT103 inhibits tumor growth and metastasis in animal models. GT103 can be used for the research of non-small cell lung cancer.
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Syk-IN-7
0 ImagesCat. No.: HY-149895CAS No.: 3050715-41-5Syk-IN-7 (compound 17) is an inhibitor of spleen tyrosine kinase (SYK).
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Syk-IN-2
0 ImagesCat. No.: HY-125585CAS No.: 1345458-66-3Syk-IN-2 (Page 78; 35) is a spleen tyrosine kinase (Syk) inhibitor.
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NMS-0963
0 ImagesCat. No.: HY-162427CAS No.: 2765304-82-1NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM.
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IQS-019
0 ImagesCat. No.: HY-124605CAS No.: 1630804-24-8IQS-019 is a B cell receptor (BCR) kinase inhibitor. IQS-019 can inhibit the de-phosphorylation of constitutive and IgM-activated Syk, Lyn, and Btk. IQS-019 can inhibit cell proliferation, migration and induce apoptosis. IQS-019 exhibits antitumor activity and can be used for the research of cancer, such as B cell lymphoma.
