2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Acetolactate Synthase (ALS)

Acetolactate Synthase (ALS)

Acetohydroxyacid synthase

Acetohydroxyacid synthase (ALS), a thiamine diphosphate-dependent enzyme, can condense either two pyruvate molecules to form acetolactate for synthesizing Lvaline and L-leucine or pyruvate with 2-ketobutyrate to form acetohydroxybutyrate for synthesizing L-isoleucine. Because the key reaction catalyzed by acetohydroxyacid synthase in the biosynthetic pathways of branched-chain amino acids (valine, leucine, and isoleucine) exists in plants, fungi, archaea, and bacteria, but not in animals, acetohydroxyacid synthase becomes a potential target for developing novel herbicides and antimicrobial compounds.

Acetolactate Synthase (ALS) Related Products (40):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158245
    Herbicide safener-2
    Herbicide safener-2 (Compound III-7) is a herbicide safener with the same pharmacokinetic profile as the safener mefenpyr-diethyl (HY-136376). Herbicide safener-2 competitively binds to the acetolactate synthase (ALS) active site with mesosulfuron-methyl (HY-126987). Herbicide safener-2 protects crops against herbicide injury.
    Herbicide safener-2
  • HY-112785R
    Pyriftalid (Standard)
    		Inhibitor
    Pyriftalid (Standard) is the analytical standard of Pyriftalid (HY-112785). This product is intended for research and analytical applications. Pyriftalid is one of the most commonly used herbicides that inhibits the synthesis of acetyl lactate synthase (ALS). Pyriftalid is mainly used to prevent poaceae weeds and some broadleaf weeds in paddy fields.
    Pyriftalid (Standard)
  • HY-W422402R
    Foramsulfuron (Standard)
    		Inhibitor
    Foramsulfuron (Standard) is the analytical standard of Foramsulfuron. This product is intended for research and analytical applications. Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids.
    Foramsulfuron (Standard)
  • HY-112785
    Pyriftalid
    		Inhibitor
    Pyriftalid is one of the most commonly used herbicides that inhibits the synthesis of acetyl lactate synthase (ALS). Pyriftalid is mainly used to prevent poaceae weeds and some broadleaf weeds in paddy fields.
    Pyriftalid
  • HY-119737R
    Chlorsulfuron (Standard)
    Chlorsulfuron (Standard) is the analytical standard of Chlorsulfuron. This product is intended for research and analytical applications. Chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of Chlorsulfuron is the enzyme acetolactate synthase.
    Chlorsulfuron (Standard)
  • HY-W040279
    Prosulfuron
    		Inhibitor
    Prosulfuron is a fluorinated sulfonylurea herbicide with a reported acute oral LD50 of 546 mg/kg in female rats. Prosulfuron acts by inhibiting acetolactate synthase (ALS) to block the biosynthesis of branched-chain amino acids (valine, leucine and isoleucine) in plants, thereby suppressing weed growth. Prosulfuron may disrupt the soil microbial community balance in alkaline soils with minimal chemical degradation. Prosulfuron has low toxicity to humans and mammals, and can be used for the research of broadleaf weed control in maize and sweet corn.
    Prosulfuron
  • HY-W721333
    Pyrimisulfan
    		Inhibitor
    Pyrimisulfan is a potent acetolactate synthase (ALS) inhibitor and a broad‑spectrum herbicide. Pyrimisulfan selectively inhibits plant acetolactate synthase. Pyrimisulfan controls a wide spectrum of paddy weeds including annual grasses, sedges, broadleaf weeds, and sulfonylurea‑resistant biotypes pre‑ and postemergence, with long residual activity and excellent rice safety. Pyrimisulfan can be used for research on paddy herbicides.
    Pyrimisulfan
  • HY-W482133
    Primisulfuron-methyl
    		Inhibitor
    Primisulfuron-methyl is a herbicide. Primisulfuron-methyl shows inhibitory activity against acetolactate synthase (ALS) enzyme. Primisulfuron-methyl can be used to selectively control annual bluegrass of Kentucky bluegrass turf.
    Primisulfuron-methyl
  • HY-W662572
    Pyroxsulam
    		Inhibitor
    Pyroxsulam is a selective, foliar-applied acetolactate synthase (ALS)-inhibiting herbicide. Pyroxsulam can be used for the study of grassy weed management in winter wheat systems.
    Pyroxsulam
  • HY-W422402
    Foramsulfuron
    		Inhibitor
    Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids.
    Foramsulfuron
  • HY-126176R
    Cloransulam-methyl (Standard)
    		Inhibitor
    Cloransulam-methyl (Standard) is the analytical standard of Cloransulam-methyl. This product is intended for research and analytical applications. Cloransulam-methyl is a triazolopyrimidine sulfonanilide herbicide. Cloransulam-methyl can be used to control broadleaf weeds in soybean by acetolactate synthase (ALS) inhibition.
    Cloransulam-methyl (Standard)
  • HY-B0869
    Bispyribac
    Bispyribac is an acetolactate synthase inhibitor that can be used as a systemic post-emergence herbicide for control of weeds in agriculture. Bispyribac blocks the amino acid synthesis. Bispyribac has low acute toxicity in animal models.
    Bispyribac
  • HY-135713
    Penoxsulam
    		Inhibitor
    Penoxsulam is an acetolactate synthase (ALS) inhibitor herbicide. Penoxsulam inhibits Candida auris acetohydroxyacid synthase (AHAS) with a Ki value of <32 nM. Penoxsulam can be used for postemergence control of annual grasses, sedges, and broadleaf weeds in rice culture. Penoxsulam can be used for the study of Candida auris infections.
    Penoxsulam
  • HY-W681876
    (E)-Pyriminobac-methyl
    		Inhibitor
    (E)-Pyriminobac-methyl is an Acetolactate synthase inhibitor and a pyrimidinylbenzoate Herbicide. (E)-Pyriminobac-methyl inhibits acetolactate synthase and blocks the biosynthesis of branched-chain amino acids. The herbicidal activity of (E)-Pyriminobac-methyl against Echinochloa crus-galli and Leptochloa chinensis is 1.5-2 times higher than that of Bensulfuron-methyl (HY-B0870).
    (E)-Pyriminobac-methyl
  • HY-126987R
    Mesosulfuron-methyl (Standard)
    		Inhibitor
    Mesosulfuron-methyl (Standard) is the analytical standard of Mesosulfuron-methyl. This product is intended for research and analytical applications. Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields.
    Mesosulfuron-methyl (Standard)
  • HY-W521246
    Tritosulfuron
    		Inhibitor
    Tritosulfuron is a sulfonylurea herbicide. Tritosulfuron has inhibitory activity against acetolactate synthase. Tritosulfuron is a broad-spectrum post-emergent dicotyledonous herbicide used in cereals, maize, and turf cultivation.
    Tritosulfuron
  • HY-170920
    Herbicide safener-4
    		Inhibitor
    Herbicide safener-4 (Compound I-15) is a Herbicide safener, improving the herbicide resistance of crops without reducing the herbicidal effect on targeted weed species. Herbicide safener-4 competitively binds to the ALS active site with Mesosulfuron-methyl (HY-126987). Herbicide safener-4 enhances GSH (HY-D0187), GST, CYP450, POD, SOD and ALS activity in plants.
    Herbicide safener-4
  • HY-W708945
    Metazosulfuron
    		Inhibitor
    Metazosulfuron is an acetolactate synthase (ALS)-inhibiting herbicide. Metazosulfuron provides complete control of pondweed (Potamogeton nodosus) and prevents its regrowth in transplanted rice ecosystems. Metazosulfuron contributes to increased rough rice grain.
    Metazosulfuron
  • HY-B0869AR
    Bispyribac sodium (Standard)
    Bispyribac (sodium) (Standard) is the analytical standard of Bispyribac sodium (HY-B0869A). This product is intended for research and analytical applications. Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits ALS activity. Bispyribac sodium blocks the biosynthesis of branched-chain amino acids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic.
    Bispyribac sodium (Standard)
  • HY-B0865R
    Pyrazosulfuron-ethyl (Standard)
    Pyrazosulfuron-ethyl (Standard) is the analytical standard of Pyrazosulfuron-ethyl. This product is intended for research and analytical applications. Pyrazosulfuron-ethyl, one of the acetolactate synthase inhibiting herbicides in the sulphonylurea family, has been widely used to control weed growth in commercial cereal, soybean, and vegetable fields.
    Pyrazosulfuron-ethyl (Standard)