Biochemical Assay Reagents Ligand
-
ZINC110492
0 ImagesCat. No.: HY-Q51222CAS No.: 100264-64-0ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS)). ZINC110492 does not bind to CS full-length (CS-FL). ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells.
-
Tetrazole-C15-(N-acetylsulfamoyl)butanoic acid
0 ImagesTetrazole-C15-(N-acetylsulfamoyl) butanoic acid is an albumin-binding ligand that extends the plasma half-life of conjugated peptides and proteins through non-covalent binding to human serum albumin; its tetrazole and N-sulfonamide groups, serving as carboxylate bioisosteres, are toxicologically safe, metabolically stable, and require no protecting groups. Tetrazole-C15-(N-acetylsulfamoyl) butanoic acid can be used in the study of growth hormone deficiency.
