100264-64-0
100264-64-0
Chemical Structure
ZINC110492
- CAS No.: 100264-64-0
- Formula:C20H12N2O4
- Molecular Weight:344.32
InChIKey: LDTSXKACGSCVEK-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C(C(N1C4=CC([N+]([O-])=O)=CC=C4)=O)C=CC=C3)C=CC=C2
Biological Activity: ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS)). ZINC110492 does not bind to CS full-length (CS-FL). ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZINC110492 | 90.0% | ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS)). ZINC110492 does not bind to CS full-length (CS-FL). ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells. | ||||||||||||||||||||
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