Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4021)
Related Products (4021)
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PPI-1040
0 ImagesCat. No.: HY-169784CAS No.: 1436673-69-6PPI-1040 is an orally bioavailable vinyl ether synthetic plasmalogen. PPI-1040 acts as a precursor of plasmalogen. PPI-1040 increases plasmalogen levels in plasmalogen-deficient mice and normalizes hyperactive behaviors in these mice. In wild-type mice, PPI-1040 retains the sn-1 vinyl ether group and sn-3 phosphoethanolamine group, and is converted into endogenous ethanolamine plasmalogen. PPI-1040 can be used in studies related to rhizomelic chondrodysplasia punctata.
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Zatosetron
0 ImagesCat. No.: HY-127030CAS No.: 123482-22-4Synonyms: LY277359Zatosetron is an active compound.
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6'-O-Glucopyranosylpaeoniflorin
0 ImagesCat. No.: HY-N17117CAS No.: 1427054-21-46'-O-Glucopyranosylpaeoniflorin is a natural terpenoid.
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Anticancer agent 203
0 ImagesCat. No.: HY-162392Anticancer agent 203 (compound 27) is an anticancer agent. Anticancer agent 203 shows cytotoxicity. Anticancer agent 203 has the potential for the research of hepatoma.
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Campesteryl ferulate
0 ImagesCat. No.: HY-W749362CAS No.: 20972-07-0Campesteryl ferulate is a component of γ-Oryzanol (HY-B2194). Campesteryl ferulate can be extracted from rice bran.
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Nle-Arg-Phe-NH2 acetate
0 ImagesCat. No.: HY-P4671CAS No.: 104809-29-2Nle-Arg-Phe-NH2 (acetate) is a tripeptide compound, usually in the form of acetate.
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Progesterone 3-biotin
0 ImagesCat. No.: HY-N0437FSynonyms: Pregn-4-ene-3,20-dione-biotinProgesterone 3-biotin (Pregn-4-ene-3,20-dione-biotin) is a biotin-labeled probe that allows progesterone to be detected or immobilized using the biotin ligand. Progesterone 3-biotin is the biotinylated derivative of Progesterone (HY-N0437).
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(11R)-12-Chloronootkaton-11-ol
0 ImagesCat. No.: HY-N16856CAS No.: 1446439-13-9(11R)-12-Chloronootkaton-11-ol is a natural sesquiterpene.
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Aspacochinoside N
0 ImagesCat. No.: HY-N19714CAS No.: 1494664-27-5Aspacochinoside N is a pregnane glycoside (steroidal saponin) found in the roots of Asparagus cochinchinensis with an IC50 > 100 μM for NO production inhibition. Aspacochinoside N can be used in research on neuroinflammation.
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LY465608
0 ImagesCat. No.: HY-114924CAS No.: 328918-26-9LY465608 is an active compound.
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Stachybotrolide
0 ImagesCat. No.: HY-N9190CAS No.: 149691-31-6Synonyms: StachybotrylactoneStachybotrolide (Stachybotrylactone) is a natural sesquiterpene.
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4-CIC hydrochloride
0 ImagesCat. No.: HY-168423CAS No.: 2749504-71-84-CIC hydrochloride is a drug derivative.
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L-647318
0 ImagesCat. No.: HY-129645CAS No.: 87770-13-6L-647318 is an active compound.
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Benzedrone
0 ImagesCat. No.: HY-W423643CAS No.: 1225617-75-3Benzedrone is a synthetic drug derivative. Benzedrone can increase the levels of neurotransmitters such as dopamine, serotonin and norepinephrine in the brain, thus producing a stimulant effect. Benzedrone can be used in the research of new psychoactive substances (NPS).
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Maltol 6'-O-β-D-apiofuranosyl-β-D-glucopyranoside
0 ImagesCat. No.: HY-N21821CAS No.: 168090-58-2Synonyms: 6'-O-β-D-ApiofuranosyldianthosideMaltol 6'-O-β-D-apiofuranosyl-β-D-glucopyranoside (6'-O-β-D-Apiofuranosyldianthoside) is a maltol glycoside that can be found in the aerial parts of Elsholtzia rugulosa Hemsl.
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Benzoadenosine
0 ImagesCat. No.: HY-114912CAS No.: 60189-62-0Synonyms: NSC 287022Benzoadenosine is an active compound.
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2'-Hydroxyisolupalbigenin
0 ImagesCat. No.: HY-N10027CAS No.: 121747-94-22'-Hydroxyisolupalbigenin (Compound 32) is a prenylated isoflavonoid that can be isolated from the roots of Lupinus albus (Kievskij Mutant).
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IDX-320
0 ImagesCat. No.: HY-19557CAS No.: 1251165-81-7IDX-320 is a Pipecolic acid (HY-Y0669) derivative. IDX-320 inhibits NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a with an IC50 0.8-1.9 nM. IDX-320 can be used in the research of HCV infection.
