Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (3977)
Related Products (3977)
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Cefazaflur
0 ImagesCat. No.: HY-167714CAS No.: 58665-96-6Cefazaflur is a novel semi-synthetic cephalosporin derivative that exhibits significant antibacterial activity, effectively inhibiting various strains of Staphylococcus aureus, Escherichia coli, Klebsiella, and Proteus mirabilis at low concentrations.
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11-Hydroxyvalenc-1(10)-en-2-one
0 ImagesCat. No.: HY-N16729CAS No.: 20489-50-311-Hydroxyvalenc-1(10)-en-2-one is a natural sesquiterpene.
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3-Deacetyl-4-demethylsalannin
0 ImagesCat. No.: HY-N18321CAS No.: 1621682-24-33-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer.
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Blumenol C
0 ImagesCat. No.: HY-N16818ACAS No.: 36151-02-7Blumenol C is a natural sesquiterpene.
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21-keto-Gypenoside A
0 ImagesCat. No.: HY-N17207CAS No.: 1392136-41-221-keto-Gypenoside A is a natural triterpene.
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9,10-Didehydroeffususol A
0 ImagesCat. No.: HY-N7712CAS No.: 1869082-57-49,10-Didehydroeffususol A is a natural phenolic compound.
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Anticancer agent 185
0 ImagesCat. No.: HY-157487Anticancer agent 185 (compound 9d) is a glycohybrid derivative of pyrazolopyrimidine [1,5-a]. Anticancer agent 185 has good anti-breast cancer activity. Anticancer agent 185 shows good cytotoxic activity against MCF-7 cells with IC50 value of 15.3 μM.
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CNP analogue-1
0 ImagesCat. No.: HY-P11861CNP analogue-1 is a long-acting, low-isoelectric point C-type natriuretic peptide (CNP) analog. CNP analogue-1 activates human natriuretic peptide receptor 2 (hNPR2) with an EC50 of 0.18 nM. CNP analogue-1 stimulates cGMP production and is resistant to neprilysin-mediated degradation. CNP analogue-1 induces baroreceptor-mediated heart rate elevation and enhances the maximal rates of cardiac contraction and relaxation. CNP analogue-1 can be used in the research of heart failure with preserved ejection fraction.
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Spongipregnoloside B
0 ImagesCat. No.: HY-N19223CAS No.: 552297-98-0Spongipregnoloside B is a pregnane diglycoside found in the rhizomes of Dioscorea spongiosa. Spongipregnoloside B can be used in osteoporosis research.
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S-27609
0 ImagesCat. No.: HY-W852084CAS No.: 151751-58-5S-27609 is an imidazoquinoline with antiviral and antitumour properties. S-27609 can induce peripheral blood mononuclear cells to produce various cytokines such as interferon-α (IFN-α), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). S-27609 is promising for research of viral infections (e.g., herpes virus) and tumors.
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3-Methyl-2-(3-methylbut-3-enoyl)-furan
0 ImagesCat. No.: HY-N16750CAS No.: 78173-38-33-Methyl-2-(3-methylbut-3-enoyl)-furan is a Furan derivative. 3-Methyl-2-(3-methylbut-3-enoyl)furan is a characteristic component of essential oils from the genus Elsholtzia.
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Hydrocortisone-21-lysinate
0 ImagesCat. No.: HY-137211CAS No.: 95924-98-4Hydrocortisone-21-lysinate is an active compound.
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Lancifodilactone I
0 ImagesCat. No.: HY-N7998CAS No.: 883153-31-9Lancifodilactone I is a natural product that can be found in Schisandra chinensis?(Turcz.) Baill..
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DRF-4015
0 ImagesCat. No.: HY-149547CAS No.: 905838-14-4DRF-4015 (Compound 22) is a betulinic acid derivative with antitumor activity.
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Trifunctional sphingosine
0 ImagesCat. No.: HY-N15947CAS No.: 2089062-80-4Trifunctional sphingosine is a clickable sphingoid base derivative. Trifunctional sphingosine can be used to study the biological function of sphingoid bases. Trifunctional lipids may overcome several challenges in interrogating lipid biology: their fast metabolism, their weak and transient (but functionally important) interactions with proteins, and the difficulty in tagging them without disturbing the cellular location.
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Salcolin B
0 ImagesCat. No.: HY-N16766CAS No.: 369390-52-3Synonyms: Tricin 4'-O-(erythro-β-guaiacylglyceryl) etherSalcolin B is a natural flavonoid.
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4-Fluoro phenibut hydrochloride
0 ImagesCat. No.: HY-118583ACAS No.: 1858241-03-8Synonyms: β-(4-Fluorophenyl)-GABA hydrochloride; F-Phenibut hydrochloride4-Fluoro phenibut (β-(4-Fluorophenyl)-GABA) hydrochloride is a Gabapentinoid and is structurally similar to known nootropics.
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9''-O-Acetylsalcolin A
0 ImagesCat. No.: HY-N17172CAS No.: 910864-92-59''-O-Acetylsalcolin A is a natural flavonoid.
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5,7-Dimethoxy-4'-hydroxyflavan
0 ImagesCat. No.: HY-N16807CAS No.: 103963-45-75,7-Dimethoxy-4'-hydroxyflavan is a natural flavonoid.
