Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4021)
Related Products (4021)
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CB-7646
0 ImagesCat. No.: HY-117001CAS No.: 104880-54-8CB-7646, a Trimelamol (HY-106768) analogue, is an anti-tumour agent. CB-7646 can be used for research of ovarian cancer and breast cancer.
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TU-2100
0 ImagesCat. No.: HY-120219CAS No.: 207972-39-2TU-2100 is an active compound.
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FP-21399
0 ImagesCat. No.: HY-19239CAS No.: 170020-61-8FP-21399 is an active compound.
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Adecypenol
0 ImagesCat. No.: HY-113716CAS No.: 104493-13-2Synonyms: OM-3223Adecypenol is an active compound.
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Artemisinin G
0 ImagesCat. No.: HY-N18336CAS No.: 98379-74-9Artemisinin G is a sesquiterpene and decomposition product of artemisinin.Artemisinin G can be found in the dry leaves of Artemisia annua L. (Compositae).
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Triptolide-6-methoxy-β-D-glucose
0 ImagesCat. No.: HY-177885CAS No.: 2003231-33-0Triptolide-6-methoxy-β-D-glucose (Compound 6) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-methoxy-β-D-glucose has no effective anti-tumor activity and is mainly used for studying the structural-activity relationship (SAR) of derivatives.
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Austamide
0 ImagesCat. No.: HY-N19716CAS No.: 34427-31-1Austamide is an indole alkaloid found in cultures of Aspergillus ustus. Austamide undergoes biosynthesis via the classical mevalonate pathway with nonface-selective reverse prenylation of its indole ring.
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Bornyval
0 ImagesCat. No.: HY-W856684CAS No.: 76-50-6Bornyval is a derivative preparation of valerian (Baldrian).
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Progesterone-3-biotinyl Photoaffinity Probe
0 ImagesCat. No.: HY-173542Synonyms: P4 Binding ProbeProgesterone-3-biotinyl Photoaffinity Probe is a compound containing active progesterone (HY-N0437). Progesterone-3-biotinyl Photoaffinity Probe can be used in the research of mechanisms related to sperm activation.
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Dendronobiloside C
0 ImagesCat. No.: HY-N17315CAS No.: 526222-23-1Dendronobiloside C is a natural product that can be found in dendrobium.
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14,15-EET-SI
0 ImagesCat. No.: HY-131721CAS No.: 218461-97-314,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA.
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Mulberrofuran W
0 ImagesCat. No.: HY-N17359CAS No.: 329319-21-3Mulberrofuran W is a 2-arylbenzofuran with a farnesyl group that exists in the root bark of Morus mongolica. It also acts as a cytotoxic agent with low cytotoxicity and weak tumor specificity.
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TTTE
0 ImagesCat. No.: HY-176218TTTE is a sulfone bischalcone derivative. TTTE has major anti-necrotic, anti-inflammatory and anti-fibrotic activities. TTTE exerts regulatory effects by downregulating key molecules such as Caspase-3, TNF-α, NF-κB and TGF-β. TTTE can be used in the study of liver injury.
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Clausine I
0 ImagesCat. No.: HY-N3993CAS No.: 182261-94-5Clausine I is a natural alkaloid.
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Daphnodorin G
0 ImagesCat. No.: HY-N16680CAS No.: 178664-65-8Daphnodorin G is a natural flavonoid.
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Croomine
0 ImagesCat. No.: HY-N18082CAS No.: 71239-66-2Croomine is a tuberostemospironine-type alkaloid. Croomine can be found in Stemona tuberosa, Croomia heterosepala, and Croomia japonica.
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Maltol 3-O-(5-O-p-coumaroyl)-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N17167CAS No.: 1018452-31-7Synonyms: 3'''-Deoxyshimobashiraside AMaltol 3-O-(5-O-p-coumaroyl)-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (3'''-Deoxyshimobashiraside A) is a natural phenolic compound.
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Dihydrospinosyn A aglycone
0 ImagesCat. No.: HY-156133CAS No.: 727695-12-7Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.
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Noueloside B
0 ImagesCat. No.: HY-N17198CAS No.: 2172630-88-3Noueloside B is a natural diterpene.
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16α-O-Ethylneoquassin
0 ImagesCat. No.: HY-N17073CAS No.: 909272-59-916α-O-Ethylneoquassin is a natural diterpene.
