2. Signaling Pathways
  3. Anti-infection
  4. EBV

EBV

Epstein-Barr Virus

Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses. EBV is found all over the world. Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva. Primary EBV infection is usually asymptomatic and for many occurs during childhood, but when it occurs in adolescence or adulthood, 30%–50% cases manifest clinically as infectious mononucleosis (IM). EBV also cause infectious mononucleosis (IM), Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC), Hodgkin’s disease, and other illnesses. Many people become infected with EBV in childhood. EBV infections in children usually do not cause symptoms, or the symptoms are not distinguishable from other mild, brief childhood illnesses.

EBV Related Products (75):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N11009
    11-Oxomogroside II A1
    		Inhibitor
    11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.
    11-Oxomogroside II A1
  • HY-P5294
    YLLEMLWRL
    		Inhibitor
    YLLEMLWRL is an HLA-A2-restricted T cell epitope sequence corresponding to codon 125-133. Among them, YLLEMLWRL sequence is the main mutation site of HLA-A2-restricted CTL epitope sequence.
    YLLEMLWRL
  • HY-N17999
    10-Hydroxypheophorbide A
    10-Hydroxypheophorbide A is a chlorophyll-related compound found in the leaves of
    Neptunia oieracea. 10-Hydroxypheophorbide A inhibits the activation of tumor promoter-induced Epstein-Barr virus (EBV) activation. 10-Hydroxypheophorbide A exhibits photo-induced cytotoxicity in cancer cells.
    10-Hydroxypheophorbide A
  • HY-P11713
    EBNA3B 399-408
    EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma.
    EBNA3B 399-408
  • HY-P11299
    EBNA-1 (386–405 aa)
    		Inhibitor
    EBNA-1 (386-405 aa) is a cross-reactive viral antigen peptide. EBNA-1 (386-405 aa) has a high molecular similarity to GlialCAM (370-389 aa) and it induces the production of cross-reactive antibodies that recognize both EBV antigens and glial cells in the central nervous system, thereby triggering autoimmune responses. EBNA-1 (386-405 aa) can used for Epstein-Barr virus (EBV) infection and multiple sclerosis (MS) research.
    EBNA-1 (386–405 aa)
  • HY-P11714
    EBNA3 246-254
    EBNA3 246-254 (RYSIFFDYM) is an EBV peptide. EBNA3 246-254 is submitted by HLA-A24. EBNA3 246-254 is amplified in vitro, followed by HLA multimer staining to measure EBV-specific CTLs. EBNA3 246-254 can be used for the research of lung cancer.
    EBNA3 246-254
  • HY-N18117A
    23-Hydroxyohchininolide
    23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease.
    23-Hydroxyohchininolide
  • HY-N18238
    11-Oxomogroside I A1
    		Inhibitor
    11-Oxomogroside I A1 is a cucurbitane-type triterpenoid glycoside and also an EBV-EA inhibitor. 11-Oxomogroside I A1 exerts 100% inhibitory effect on the induction of EBV-EA. 11-Oxomogroside I A1 can be used for cancer research.
    11-Oxomogroside I A1
  • HY-130789
    Cimigenol-3-one
    		Inhibitor
    Cimigenol-3-one inhibits Epstein-Barr virus early antigen (EBV-EA) activation.
    Cimigenol-3-one
  • HY-P10772
    L2P4
    		Inhibitor
    L2P4 is a peptide-based and EBNA1 targeting fluorescent probe, which inhibits the EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. L2P4 exhibits cytotoxicity in EBV-positive C666-1 cell with LC50 of 46.4 μM.
    L2P4
  • HY-W714047
    Valerianol
    		Inhibitor
    Valerianol is a sesquiterpene alcohol with anticancer, antibacterial, and antiviral activities. Valerianol selectively inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen (EBV-EA) activation (IC50=300 μM). Valerianol inhibits tumor promoter-mediated EBV-EA activation and also inhibits pathogenic bacteria such as Staphylococcus aureus.
    Valerianol
  • HY-P1911
    CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)
    CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters.
    CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)
  • HY-N9752
    Mogroside II B
    		Inhibitor
    Mogroside II B is a cucurbitane-type glycoside with a sweet taste in water. Mogroside II B inhibits the activation of Epstein Barr virus early antigen (EBV-EA) induced by Phorbol 12-myristate 13-acetate (TPA) (HY-18739). Mogroside II B exerts weak inhibitory effects on the activation of the nitric oxide (NO) donor (NOR1).
    Mogroside II B
  • HY-N18106
    Amygdalinic acid
    		Inhibitor
    Amygdalinic acid (Compound 3) is a glycoside. Amygdalinic acid can be isolated from Persicae Semen. Amygdalinic acid inhibits Epstein-Barr virus early antigen activation. Amygdalinic acid delays two-stage chemical carcinogenesis in mouse skin, reduces papilloma incidence.
    Amygdalinic acid
  • HY-N3254
    Minumicrolin
    Minumicrolin is a plant growth inhibitor. Minumicrolin can be isolated from Murraya paniculata. Minumicrolin inhibits Epstein-Barr virus early antigen (EBV-EA) activation.
    Minumicrolin
  • HY-148170
    L-I-OddU
    		Inhibitor
    L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis.
    L-I-OddU
  • HY-P1920
    CEF19, Epstein-Barr Virus latent NA-3A (458-466)
    CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition.
    CEF19, Epstein-Barr Virus latent NA-3A (458-466)
  • HY-N18117
    21-Hydroxyisoohchininolide
    		Inhibitor
    21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases.
    21-Hydroxyisoohchininolide
  • HY-N17354
    Glycocitrine II
    		Inhibitor
    Glycocitrine II is an acridone alkaloid. Glycocitrine II can be isolated from the Rutaceous plants. Glycocitrine II inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced EBV-EA activation.
    Glycocitrine II
  • HY-N15758
    Amorphispironone
    		Inhibitor
    Amorphispironone (Compound 1) is a rotenoid that can be isolated the leaves of A. fruticosa. Amorphispironone exhibits remarkable inhibitory effects on EBV-EA activation induced by TPA. Amorphispironone exhibits potent anti-tumor-promotion activity on mouse skin tumor promotion in vivo.
    Amorphispironone