11-Oxomogroside I A1

Cat. No.: HY-N18238: Data Sheet Handling Instructions
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11-Oxomogroside I A1 is a cucurbitane-type triterpenoid glycoside and also an EBV-EA inhibitor. 11-Oxomogroside I A1 exerts 100% inhibitory effect on the induction of EBV-EA. 11-Oxomogroside I A1 can be used for cancer research.

For research use only. We do not sell to patients.

11-Oxomogroside I A1 Chemical Structure

CAS No. : 476468-78-7

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Description

In Vitro

11-Oxomogroside I A1 (10-1×10³ mol ratio/TPA; 48 h) potently inhibits TPA-induced EBV-EA induction in Raji cells, achieving 100% inhibition at 1×10³ mol ratio/TPA while maintaining 70% cell viability, with decreasing inhibitory effects at lower mol ratios relative to TPA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:	Raji cells (human lymphoblastoid cells carrying EBV genome)
Concentration:	10-1×10³ mol ratio/TPA
Incubation Time:	48 h
Result:	Reduced EBV-EA induction to 0% relative to the TPA-only positive control at 1×10³ mol ratio/TPA, with 70% Raji cell viability. Reduced EBV-EA induction to 29.0% relative to the positive control at 500 mol ratio/TPA. Reduced EBV-EA induction to 77.4% relative to the positive control at 100 mol ratio/TPA. Reduced EBV-EA induction to 97.2% relative to the positive control at 10 mol ratio/TPA.

Molecular Weight

636.86

Formula

C₃₆H₆₀O₉

CAS No.

476468-78-7

SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)([C@H](CC4)O)C)=CC3)(C(C[C@@]1([C@@](CC2)([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ukiya M, et al. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. J Agric Food Chem. 2002;50(23):6710-6715. [Content Brief]