2. Anti-infection
  3. EBV
  4. Amygdalinic acid

Amygdalinic acid (Compound 3) is a glycoside. Amygdalinic acid can be isolated from Persicae Semen. Amygdalinic acid inhibits Epstein-Barr virus early antigen activation. Amygdalinic acid delays two-stage chemical carcinogenesis in mouse skin, reduces papilloma incidence.

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Amygdalinic acid

Amygdalinic acid Chemical Structure

CAS No. : 66427-92-7

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Amygdalinic acid Related Antibodies

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Description

Amygdalinic acid (Compound 3) is a glycoside. Amygdalinic acid can be isolated from Persicae Semen. Amygdalinic acid inhibits Epstein-Barr virus early antigen activation. Amygdalinic acid delays two-stage chemical carcinogenesis in mouse skin, reduces papilloma incidence[1].

In Vitro

Amygdalinic acid (10-1000 mol ratio/TPA; 48 h) inhibits EBV-EA activation in Raji cells in a concentration-dependent manner, with the strongest inhibition (3.5 ± 0.3% relative control) observed at 1000 mol ratio/TPA and 60% cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amygdalinic acid Related Antibodies

Immunofluorescence[1]

Cell Line: Raji cells (Burkitt's lymphoma-derived lymphoblastoid cells)
Concentration: 10-1000 mol ratio/TPA
Incubation Time: 48 h
Result: Reduced EBV-EA activation to 3.5 ± 0.3% relative to the positive control, with 60% Raji cell viability at 1000 mol ratio/TPA.
Reduced EBV-EA activation to 34.1 ± 1.2% relative to the positive control, with >80% Raji cell viability at 500 mol ratio/TPA.
Reduced EBV-EA activation to 65.0 ± 1.9% relative to the positive control, with >80% Raji cell viability at 100 mol ratio/TPA.
Reduced EBV-EA activation to 95.7 ± 0.4% relative to the positive control, with >80% Raji cell viability at 10 mol ratio/TPA.
In Vivo

Amygdalinic acid (85 nmol; twice weekly) exhibits anti-tumor promoting activity in a two-stage skin carcinogenesis mouse model, reducing the incidence of papillomas to a level comparable to that of (-)-Epigallocatechin gallate (HY-13653)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

476.43

Formula

C20H28O13
CAS No.
SMILES

OC([C@@H](C1=CC=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Amygdalinic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amygdalinic acid66427-92-7EBVEpstein-Barr VirusAC755 tumor cells12-O-tetradecanoylphorbol 13-acetatePrunus persicaEpstein-Barr virus early antigenskin papilloma(-)-epigallocatechin gallateRaji cellsmouse two-stage skin carcinogenesis modelmouse skinInhibitorinhibitorinhibit

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