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Cat. No.: HY-N18106

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Amygdalinic acid

Amygdalinic acid (Compound 3) is a glycoside. Amygdalinic acid can be isolated from Persicae Semen. Amygdalinic acid inhibits Epstein-Barr virus early antigen activation. Amygdalinic acid delays two-stage chemical carcinogenesis in mouse skin, reduces papilloma incidence.

For research use only. We do not sell to patients.

CAS No.: 66427-92-7
Formula: C₂₀H₂₈O₁₃
Molecular Weight:476.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Amygdalinic acid Chemical Structure

CAS No.: 66427-92-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Amygdalinic acid (10-1000 mol ratio/TPA; 48 h) inhibits EBV-EA activation in Raji cells in a concentration-dependent manner, with the strongest inhibition (3.5 ± 0.3% relative control) observed at 1000 mol ratio/TPA and 60% cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

Raji cells (Burkitt's lymphoma-derived lymphoblastoid cells)
Concentration:

10-1000 mol ratio/TPA
Incubation Time:

48 h
Result:

Reduced EBV-EA activation to 3.5 ± 0.3% relative to the positive control, with 60% Raji cell viability at 1000 mol ratio/TPA.
Reduced EBV-EA activation to 34.1 ± 1.2% relative to the positive control, with >80% Raji cell viability at 500 mol ratio/TPA.
Reduced EBV-EA activation to 65.0 ± 1.9% relative to the positive control, with >80% Raji cell viability at 100 mol ratio/TPA.
Reduced EBV-EA activation to 95.7 ± 0.4% relative to the positive control, with >80% Raji cell viability at 10 mol ratio/TPA.

In Vivo

Amygdalinic acid (85 nmol; twice weekly) exhibits anti-tumor promoting activity in a two-stage skin carcinogenesis mouse model, reducing the incidence of papillomas to a level comparable to that of (-)-Epigallocatechin gallate (HY-13653)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 66427-92-7
Molecular Weight 476.43
Formula C₂₀H₂₈O₁₃
SMILES

OC([C@@H](C1=CC=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fukuda T, et al. Anti-tumor promoting effect of glycosides from Prunus persica seeds. Biol Pharm Bull. 2003;26(2):271-273. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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