FOXP4
FOXP4 belongs to the forkhead box protein P (FOXP) family. FOXP4 is highly expressed in the nervous system and regulate molecular pathways required for proper brain development and function. FOXP4 is closely associated with miR 4316 in breast cancer cells, miR 491-5p in osteosarcoma and miR 338-3p in hepatocellular carcinoma. FOXP4 is closely associated with FOXP1 and FOXP2 with 54 and 60% identity, respectively since FOXP4 forms a large multidomain transcriptional repressors with FOXP1 and FOXP2. FOXP4 is overexpressed in A549 and H1703 non-small cell lung cancer (NSCLC) cells and conversely FOXP4 depletion markedly reduced the growth and invasion of above two NSCLCs[1][2].
References:
- [1]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
- [2]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
