Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N15971

DSPE-PEG(2000) Succinyl ammonium		98.0%
DSPE-PEG(2000) Succinyl ammonium is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.

HY-109506S9

DPPC-¹³C₂
DPPC-13C2 is a deuterated labeled DPPC. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.

HY-140956

DSPE-PEG8-Mal		99.86%
DSPE-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-159859

IZ-Chol		99.4%
IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect.

HY-144021

14:0 EPC chloride		99.13%
14:0 EPC chloride is an acyl cationic lipid that can be used for liposomes applied in drug delivery.

HY-P11143A

IL4RPep-1 acetate		98.61%
IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors.

HY-151512

A12-Iso5-4DC19		98.32%
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines.

HY-151511

A12-Iso5-2DC18
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle.

HY-159865

CL15F6		98.7%
CL15F6 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.

HY-153545

9-Amino-NeuAc		98.92%
9-Amino-NeuAc is a substrate of synthase. 9-Amino-NeuAc can be converted to CMP9-amino-NeuAc, activated to the corresponding CMPglycoside and transferred to asialoglycoprotein. 9-Amino-NeuAc can be used to target liposome synthesis while modulating tumor surface immunogenicity.

HY-156936

RCB-02-4-8		99.3%
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice.

HY-156985

Lipid AX4		98.5%
Lipid AX4 is an ionizable cationic lipid with the _pK_a of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.

HY-142984

Decanoic acid, 2-hexyl-, 6-oxohexyl ester-1		99.71%
Decanoic acid, 2-hexyl-, 6-oxohexyl ester-1 is a lipid product can be used for drug delivery.

HY-172279C

DSPE-PEG3400-TAT
DSPE-PEG3400-TAT is a PEG compound which composed of DSPE and a cell-penetrating peptide (TAT) (HY-P0281). DSPE-PEG3400-TAT can be used for drug delivery.

HY-172018

CP-LC-0729
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).

HY-145486

1-Arachidonoyl-sn-glycerol 3-phosphate ammonium
1-Arachidonoyl-sn-glycerol 3-phosphate ammonium (20:4 Lyso PA) is a phospholipid and an LPA derived from arachidonic acid. The concentration of 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium in plasma is significantly correlated with the age of onset of cocaine use and the duration of abstinence. 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium can be used in the research of biomarkers for cocaine use disorder (CUD).

HY-182100A

DSPE-PEG2000-MTP
DSPE-PEG2000-MTP is a PEG compound which composed of DSPE and a muscle-targeting peptide (MTP). MTP is a muscle-targeting peptide with the property of targeting muscle tissue. DSPE-PEG2000-MTP can be used for drug delivery.

HY-150240

DOPE-GA		≥98.0%
DOPE-GA can be used in the preparation of liposomes for research on drug delivery and other applications.

HY-W590676

Tetramyristoylcardiolipin diammonium		99%
Tetramyristoylcardiolipin (TMCL) is an anionic lipid. Tetramyristoylcardiolipin can be used to study cell membrane function and drug delivery.

HY-172473

DSPE-PEG2000-NGR
DSPE-PEG2000-NGR is a PEG compound which composed of DSPE and an Asn-Gly-Arg (NGR) peptide. NGR peptide can target tumor vascular antigen CD13. DSPE-PEG2000-NGR can be used for drug delivery.

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