2. Signaling Pathways
  3. Immunology/Inflammation
  4. NTPDase

NTPDase

Nucleoside triphosphate diphosphohydrolases

Ectonucleoside triphosphate diphosphohydrolase (NTPDase), belonging to the CD39/apyrase family of hydrolases, exists in various organisms including mammals, plants, yeast, and protozoa. NTPDase catalyzes the hydrolysis of nucleoside triphosphates (such as ATP, GTP) and diphosphates (such as ADP, GDP) to produce corresponding nucleoside monophosphates (such as AMP, GMP) and inorganic phosphate (Pi). Additionally, NTPDase participates in the dynamic balance of purinergic signaling pathways by regulating extracellular nucleotide levels.
There are 8 subtypes of NTPDase (NTPDase1-8). Members of this family that are localized to the cell surface are able to regulate the concentration of nucleotides that act as agonists for purinergic and pyrimidinergic receptor signaling. Among them, NTPDase4 and NTPDase7 are located on the inner membrane of cells. NTPDase5 and NTPDase6 are also present in the inner membrane, but after their single N-terminal transmembrane signal sequence is cleaved, they can be secreted in a soluble form. Furthermore, NTPDase1 (also known as CD39) and NTPDase2 (also known as ecto-ATPase), NTPDase3 (also known as HB6 or CD39L3), and NTPDase8 are all located on the cell surface membrane with their active sites located extracellularly. These cell surface nucleotidases are capable of hydrolyzing extracellular nucleotides that activate purinergic receptors (P2X and P2Y), which conduct signaling through G proteins (metabotropic P2Y receptor family) or are themselves ligand-gated ion channels (ionic P2X receptor family).
NTPDase is involved in various physiological and pathological processes, including inflammation, vasodilation, tumor progression, and regulation of immune responses[1][2][3].

NTPDase Isoform Specific Products:

NTPDase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991701
    Mebarase alfa
    		Inhibitor
    Mebarase alfa is a human monoclonal antibody targeting ENTPD1/CD39 for the study of sepsis-associated renal injury.
    Mebarase alfa
  • HY-B0153AS
    Ticlopidine-d4 hydrochloride
    		Inhibitor
    Ticlopidine-d4 hydrochloride is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
    Ticlopidine-d<sub>4</sub> hydrochloride
  • HY-155596
    h-NTPDase-IN-1
    		Inhibitor
    h-NTPDase-IN-1 (Compound 3i) is a h-NTPDase inhibitor (IC50: 2.88 μM and 0.72 μM for h-NTPDase1 and h-NTPDase3 respectively). h-NTPDase-IN-1 can be used for research of thrombosis, inflammation, diabetes, and cancer.
    h-NTPDase-IN-1
  • HY-143289
    NTPDase-IN-3
    		Inhibitor
    NTPDase-IN-3 (Compound 5e) is a NTPDase inhibitor, with IC50 values of: 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). NTPDase-IN-3 can be used in the research of cancers and thrombosis.
    NTPDase-IN-3
  • HY-P990038
    Eurestobart
    		Inhibitor 99%
    Eurestobart (ES002023) is a recombinant human IgG1 antibody against CD39. Eurestobart restores antitumor immunity by stabilizing the pro-inflammatory extracellular ATP (eATP) and interfering with synthesis of the immunosuppressive adenosine within the tumor microenvironment (TME). Eurestobart is used in the research of locally advanced and metastatic solid tumors.
    Eurestobart
  • HY-123549
    PSB-6426
    		Inhibitor
    PSB-6426 (compund 19a) is a selective human NTPDase2 inhibitor (Ki=8.2 μM). PSB-6426 can be used in stroke and cancer research.
    PSB-6426
  • HY-155827
    h-NTPDase-IN-3
    		Inhibitor
    h-NTPDase-IN-3 (compound 4d) is a pan-inhibitor of NTPDase with IC50s of 34.13 μM (h-NTPDase1), 0.33 μM (h-NTPDase2), 23.21 μM (h-NTPDase3), 2.48 μM (h- NTPDase8).
    h-NTPDase-IN-3
  • HY-143287
    NTPDase-IN-1
    		Inhibitor
    NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a Km of 21 µM for h-NTPDase-1. NTPDase-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections.
    NTPDase-IN-1
  • HY-155597
    h-NTPDase8-IN-1
    		Inhibitor
    h-NTPDase8-IN-1 (compound 2d) is a sulfamoyl-benzamides based and selective inhibitor for h-NTPDases8 (IC50=0.28 μM). h-NTPDases8 is involved in a variety of physiological and pathological functions，such as thrombosis，diabetes，inflammation，and cancer.
    h-NTPDase8-IN-1
  • HY-183701
    CD73/NTPDase1-IN-1
    		Inhibitor
    CD73/NTPDase1-IN-1 is a dual NTPDase1 and CD73 inhibitor, with IC50 values of 2.20 μM and 1.70 μM against human targets, respectively. CD73/NTPDase1-IN-1 can be used in the research of diseases such as inflammation, immunity and tumors.
    CD73/NTPDase1-IN-1
  • HY-155828
    h-NTPDase-IN-4
    		Inhibitor 98.64%
    h-NTPDase-IN-4 (compound 4c) is a pan-inhibitor of NTPDase with IC50s of 3.58 μM (h-NTPDase1), 10.21 μM (h-NTPDase2), 0.13 μM (h-NTPDase3), 13.57 μM (h- NTPDase8).
    h-NTPDase-IN-4
  • HY-181981
    NTPDase/NPP1-IN-1
    		Inhibitor
    NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC50 values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer.
    NTPDase/NPP1-IN-1
  • HY-P992099
    Afivastobart
    		Inhibitor
    Afivastobart (AB598) is a human ENTPD1 (CD39)-targeting monoclonal antibody with antineoplastic activity.Afivastobart binds as a monoclonal antibody to modulate Homo sapiens ENTPD1 activity.Afivastobart constitutes a glycoform alfa immunoglobulin G1-kappa monoclonal antibody.
    Afivastobart
  • HY-103263R
    PSB-06126 (Standard)
    		Inhibitor
    PSB-06126 (Standard) is the analytical standard of PSB-06126 (HY-103263). This product is intended for research and analytical applications. PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM.
    PSB-06126 (Standard)
  • HY-B0153AR
    Ticlopidine hydrochloride (Standard)
    		Inhibitor
    Ticlopidine hydrochloride (Standard) is the analytical standard of Ticlopidine hydrochloride (HY-B0153A). This product is intended for research and analytical applications. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
    Ticlopidine hydrochloride (Standard)
  • HY-168001
    TcNTPDase1-IN-1
    		Inhibitor
    TcNTPDase1-IN-1 (compound 16) is an inhibitor of nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1) from Trypanosoma cruzi in vitro. TcNTPDase1-IN-1 can be used in antibacterial, antitoxic and antitumor related research.
    TcNTPDase1-IN-1
NTPDase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.