2. Immunology/Inflammation
  3. NTPDase CD73
  4. CD73/NTPDase1-IN-1

CD73/NTPDase1-IN-1 is a dual NTPDase1 and CD73 inhibitor, with IC50 values of 2.20 μM and 1.70 μM against human targets, respectively. CD73/NTPDase1-IN-1 can be used in the research of diseases such as inflammation, immunity and tumors.

For research use only. We do not sell to patients.

CD73/NTPDase1-IN-1

CD73/NTPDase1-IN-1 Chemical Structure

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CD73/NTPDase1-IN-1 Related Antibodies

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Description

CD73/NTPDase1-IN-1 is a dual NTPDase1 and CD73 inhibitor, with IC50 values of 2.20 μM and 1.70 μM against human targets, respectively. CD73/NTPDase1-IN-1 can be used in the research of diseases such as inflammation, immunity and tumors[1].

IC50 & Target[1]

NTPDase1

2.2 μM (IC50)

In Vitro

CD73/NTPDase1-IN-1 (Compound 5n) is a dual NTPDase1 and CD73 inhibitor. Ectonucleotidases can regulate extracellular purinergic signaling pathways by converting adenosine triphosphate into adenosine; these pathways play a key role in immune responses, inflammatory reactions, and tumor progression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CD73/NTPDase1-IN-1 Related Antibodies
Molecular Weight

468.52

Formula

C20H19F3N4O2S2
SMILES

O=S(N1C2=CC=C(/C=N/NC(NC3=C(C(F)(F)F)C=CC=C3)=S)C=C2C=C1)(CCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CD73/NTPDase1-IN-1 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD73/NTPDase1-IN-1NTPDaseCD73Nucleoside triphosphate diphosphohydrolasesecto-5′-nucleotidase, NT5EAsp-506human ecto-5′-nucleotidaseNTPDase1Phe-417Arg-441catalytic pockethydrogen bondsπ-π stackingmolecular dynamics simulationsInhibitorinhibitorinhibit

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CD73/NTPDase1-IN-1
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HY-183701
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