2. Immunology/Inflammation
  3. NTPDase
  4. Eurestobart

Eurestobart  (Synonyms: ES002023)

Cat. No.: HY-P990038 Purity: 99%
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Eurestobart (ES002023) is a recombinant human IgG1 antibody against CD39. Eurestobart restores antitumor immunity by stabilizing the pro-inflammatory extracellular ATP (eATP) and interfering with synthesis of the immunosuppressive adenosine within the tumor microenvironment (TME). Eurestobart is used in the research of locally advanced and metastatic solid tumors.

For research use only. We do not sell to patients.

CAS No. : 2682847-53-4

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Based on 1 publication(s) in Google Scholar

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Description

Eurestobart (ES002023) is a recombinant human IgG1 antibody against CD39. Eurestobart restores antitumor immunity by stabilizing the pro-inflammatory extracellular ATP (eATP) and interfering with synthesis of the immunosuppressive adenosine within the tumor microenvironment (TME). Eurestobart is used in the research of locally advanced and metastatic solid tumors[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

ENTPD1/CD39
In Vitro

Upon binding to CD39, Eurestobart inhibits its enzymatic activity, thereby blocking the hydrolysis process of ATP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eurestobart Related Antibodies
Gene ID

953  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.882 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Eurestobart]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Eurestobart on ProA biosensor, can bind HY-P75417 CD39 Protein, Human (sf9, His) with an affinity constant of 2.503E-09 M as determined in BLI assay.
Purity & Documentation
References
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Eurestobart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eurestobart2682847-53-4ES002023ES 002023ES-002023NTPDaseNucleoside triphosphate diphosphohydrolasesCD39IgG1 antibodymetastatic solid tumorslocally advanced solid tumorsInhibitorinhibitorinhibit

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