2. Apoptosis
  3. Apoptosis
  4. AN5777

AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity .

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AN5777

AN5777 構造式

CAS 番号 : 491586-42-6

容量 価格（税別） 在庫状況 数量
5 mg $135 在庫あり
10 mg $215 在庫あり
25 mg $430 在庫あり
50 mg $690 在庫あり
100 mg $1100 在庫あり
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500 mg   お問い合わせ  

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AN5777 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity [1].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
16.74 μM
Compound: AN5777
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
[PMID: 38795517]
OCI-AML2 IC50
2.64 μM
Compound: AN5777
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
[PMID: 38795517]
U-266 IC50
3.8 μM
Compound: AN5777
Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
[PMID: 38795517]
U-937 IC50
4.49 μM
Compound: AN5777
Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
[PMID: 38795517]
分子量

319.36

分子式

C19H17N3O2
CAS 番号
Appearance

Solid

Color

Off-white to gray

SMILES

CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
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AN5777 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN5777491586-42-6AN 5777AN-5777ApoptosisGSPT1DegraderAntitumorCRBNInhibitorinhibitorinhibit

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製品名:
AN5777
製品番号:
HY-161696
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