Anti-Rat TCR alpha/beta Antibody (R73)
Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β+ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Rat
In Vivo
Anti-Rat TCR alpha/beta Antibody (R73) (0.5 mg/kg, i.v., once daily, for 5 days) significantly reduces blood sugar levels combined with IL-6 mAb and IL-17A mAb (HY-P990222) in IDDM rats with a diabetes model[2].
Anti-Rat TCR alpha/beta Antibody (R73) (0.1 mg/kg, i.p., once daily, for 7 days) significantly prolongs the survival time of kidney transplants in BN rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CFA induced female Dark Agouti mice (90-100 g)[1]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), on day 14, 15, 16, 17, 18, 20 and 22
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Result:Significantly inhibited the progression of arthritis.
Significantly reduced synovial hyperplasia and inflammatory cell infiltration.
Caused mild cartilage erosion.
Effectively eliminated T cells from peripheral blood and synovial tissue.
Inhibited cellular immune response.
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Animal Model:IDDM rats[2]
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Dosage:0.5 mg/kg, combined with IL-6 mAb (0.01 mg/kg) and IL-17A mAb (0.1 mg/kg)
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Administration:Intravenous injection (i.v.), once daily, for 5 days
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Result:Significantly reduced blood sugar to normal levels.
Significantly increase the quality of β cells.
Reduced pancreatic islet immune cell infiltration.
Reduced the apoptosis rate of β cells and promoted β cell proliferation.
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Animal Model:BN rats (10-14 weeks)[3]
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Dosage:0.1 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily, for 7 days
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Result:Significantly prolonged the survival time of kidney transplants (long-term survival or complete acceptance of transplants).
Reduced the levels of IgM and IgG homologous antibodies.
Upregulated Th2 cytokines (IL-4 and IL-10) in the transplant and inhibited Th1 cytokines (IL-2 and IFN-γ).
Significantly reduced the infiltration of T cells and neutrophils within the graft.
Inhibited the expression of pro-inflammatory cytokines (IL-1β and TNF-α) in the graft.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo administration
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Rat TCR alpha/beta Antibody (R73)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yoshino S, et al. Depletion of alpha/beta T cells by a monoclonal antibody against the alpha/beta T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J Exp Med. 1992 Apr 1;175(4):907-15. [Content Brief]
[2]. Jörns A, et al. Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes. BMC Med. 2020 Feb 28;18(1):33. [Content Brief]
[3]. Heidecke CD, et al. Importance of T cells to accelerated rejection and acceptance of renal allografts in sensitized rat recipients. Transplantation. 1998 Nov 27;66(10):1354-61. [Content Brief]
[4]. ung S, et al. Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta. J Immunol. 1992 Jun 15;148(12):3768-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Rat TCR alpha/beta Antibody (R73) Related Classifications
HY-P990160 Related Classifications
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