AFAP1 Antibody (YA8689)
(Synonyms: AFAP; AFAP-110; AFAP110)AFAP1 Antibody (YA8689) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AFAP1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
AFAP1 Antibody (YA8689) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AFAP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 80.5 kDa
Human recombinant protein fragment corresponding to amino acids 100-386 of human AFAP1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AFAP1 is a Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells
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Subcellular Localization
Cytoplasm, cytoskeleton, stress fiber
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Expression
Tissue_Specificity: Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma -
Isoforms & Post-Translational Modification
Q8N556 has two isomers: Q8N556-1: 80725 Da (predicted); Q8N556-2: 89795 Da (predicted).
Phosphorylated on tyrosine residues by SRC -
Subunit
Monomer and homomultimer
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SwissProt ID
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Synonyms
AFAP; AFAP-110; AFAP110
Documentation
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