ENPP1/PC1 Antibody (YA7735)
ENPP1/PC1 Antibody (YA7735) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENPP1/PC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in phosphate buffered saline(pH 7.4), Glycerol, BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:200-1000 | 1:200-1000 |
Product Details
ENPP1/PC1 Antibody (YA7735) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENPP1/PC1.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 100 kDa;
KLH conjugated synthetic peptide derived from human ENPP1
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in phosphate buffered saline(pH 7.4), Glycerol, BSA.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ENPP1/PC1 is a Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect. Appears to modulate insulin sensitivity and function. Also involved in melanogenesis. Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production. 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cell membrane,Basolateral cell membrane,Secreted
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Expression
Tissue_Specificity: Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis (PubMed:9344668). Expressed in melanocytes but not in keratinocytes (PubMed:28964717) -
Isoforms & Post-Translational Modification
P22413: 925 amino acids, molecular weight 104924 Da.
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Subunit
Homodimer (PubMed:28964717)
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SwissProt ID
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