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Niemann Pick C2 Antibody (YA1399)(PBS only)

(Synonyms: HE1; EDDM1)

Niemann Pick C2 Antibody (YA1399) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Niemann Pick C2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-1:1000 500-1:2000

Product Details

Description

Niemann Pick C2 Antibody (YA1399) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Niemann Pick C2.

  • Host Rabbit
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 17 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 17 kDa
Immunogen

Recombinant protein of human Niemann Pick C2 aa20-151.

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Niemann Pick C2 is an Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport[1][2][3][4][5][6][7].

  • Subcellular Localization

    Secreted; Endoplasmic reticulum; Lysosome

  • Expression


    Tissue_specificity:Detected in gallbladder bile (PubMed:21315718) . Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level) (PubMed:11125141) . Epididymis

    Induction:Down-regulated in response to enterovirus 71 (EV71) infection

  • Isoforms & Post-Translational Modification

    P61916 has 2 isomers: P61916-1: 16570 Da (predicted); P61916-2: 13416 Da (predicted).

  • Subunit

    Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner (PubMed:18772377, PubMed:27238017, PubMed:27551080).

  • SwissProt ID

    P61916

  • Gene ID
    10577 [NCBI]
  • Synonyms

    HE1; EDDM1

  • Research Field

    Cardiovascular

Niemann Pick C2 Antibody (YA1399)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Niemann Pick C2 Antibody (YA1399)(PBS only) Product Image