NRBF2 Antibody (YA8703)

Cat. No.: HY-P89019: Data Sheet User Guide for Antibodies
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NRBF2 Antibody (YA8703) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NRBF2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NRBF2 Antibody (YA8703) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NRBF2.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96F24

Immunogen

Full length human recombinant protein of human NRBF2 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)|Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity)

Subcellular Localization：Nucleus,Cytoplasm,Cytoplasmic vesicle,Cytoplasmic vesicle, autophagosome

Expression：
Tissue_Specificity: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852)

Isoforms & Post-Translational Modification：Q96F24 has three isomers: Q96F24-1: 32378 Da (predicted); Q96F24-2: 26955 Da (predicted); Q96F24-3: 31001 Da (predicted).

Subunit：Interacts with PPARA, PPARD and PPARG

Synonyms

COPR; COPR1; COPR2; NRBF-2

Documentation

User Guide for Antibodies (1077 KB)