PCPTP1 Antibody (YA1549)
(Synonyms: PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7)PCPTP1 Antibody (YA1549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCPTP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
PCPTP1 Antibody (YA1549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCPTP1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityRat
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Observed Molecular WeightObserved band size: 74 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 74 kDa
Entrez Gene: 94202 Rat
SwissProt: O08617 Rat
A synthetic peptide of human PCPTP1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PCPTP1 sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus
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Subcellular Localization
Secreted; Cell membrane; Single-pass type I membrane protein; Cytoplasm, perinuclear region; Cytoplasm, perinuclear region
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Expression
Tissue_specificity:Detected in cerebrospinal fluid (at protein level) (PubMed:25326458) . Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus -
Isoforms & Post-Translational Modification
Q15256 has 4 isomers: Q15256-1: 73834 Da (predicted); Q15256-3: 46581 Da (predicted); Q15256-4: 51046 Da (predicted); Q15256-5: 61415 Da (predicted).
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Subunit
Interacts with MAPKs
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SwissProt ID
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Synonyms
PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7
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Research Field
Signal Transduction
Documentation
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