Art. -Nr.: HY-B1092A

Gluconate sodium

(Synonyms: D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt)

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Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.

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Reinheit: ≥98.0%
CAS. Nr.: 527-07-1
Formel: C₆H₁₁NaO₇
Molecular Weight:218.14

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Gluconate sodium Chemical Structure

CAS. Nr.: 527-07-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Gluconate sodium (0.5-3 mM; 5 min) inhibits thrombin-induced arachidonic acid peroxidation and superoxide anion production in platelets, reduces platelet protein oxidation/nitration, and decreases carbonyl group generation, thiol oxidation, and nitrotyrosine formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Gluconate sodium (50 g/kg of basal diet; orally; 33 weeks) increases the cecal butyrate concentration in rats and reduces the tumor incidence and the average number of tumors in rats with induced colorectal cancer^[2].
Gluconate sodium (50 mg/kg body weight; once a day for 5 weeks) regulates the changes in hematological parameters induced by Dimethylhydrazine (HY-W460407) in mice, reduces the levels of lipid peroxidation and nitric oxide (NO) in colon tissues, and improves the pathological changes of colon tissues^[3].
Gluconate sodium (2500 ppm; in diet; p.o.; 15 days) increases the average daily gain of weaned piglets, reduces the feed-to-gain ratio, alleviates the intestinal injury induced by recombinant Escherichia coli, and improves the intestinal morphology^[4].
Gluconate sodium (Calcium gluconate; 50 mg/kg; p.o.; 84 days) alleviates the symptoms of osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats, and inhibits joint stiffness and cartilage damage^[5].
Gluconate sodium (Calcium gluconate; 12.5-50 mg/kg; i.p.; 30 min after modeling) alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice, and inhibits the infiltration of inflammatory cells and the release of inflammatory cytokines^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice (4-6 weeks); acute lung injury model induced by lipopolysaccharide^[6]
Dosage:

12.5, 25, 50 mg/kg
Administration:

Intraperitoneally injected, 30 min after modeling
Result:

Inhibited airway inflammatory injury and the release of inflammatory cytokines such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid.
Inhibited ERK phosphorylation, protecting the mouse airway from LPS-induced inflammatory response.

Chemical Information

CAS. Nr. 527-07-1
Appearance Solid
Molecular Weight 218.14
Formel C₆H₁₁NaO₇
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O[Na])=O
Synonyms

D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- other families
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : ≥ 100 mg/mL (458.42 mM)

DMSO : 1 mg/mL (4.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5842 mL

22.9211 mL

45.8421 mL

5 mM

0.9168 mL

4.5842 mL

9.1684 mL

10 mM

0.4584 mL

2.2921 mL

4.5842 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (229.21 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Saluk-Juszczak J. A comparative study of antioxidative activity of calcium-D-glucarate, sodium-D-gluconate and D-glucono-1,4-lactone in a human blood platelet model. Platelets. 2010;21(8):632-40. [Content Brief]

[2]. Kameue C, et al. Dietary sodium gluconate protects rats from large bowel cancer by stimulating butyrate production. J Nutr. 2004 Apr;134(4):940-4. [Content Brief]

[3]. Saleem TH, et al. Possible Protective Effects of Quercetin and Sodium Gluconate Against Colon Cancer Induction by Dimethylhydrazine in Mice. Asian Pac J Cancer Prev. 2015;16(14):5823-8. [Content Brief]

[4]. Zhang Y, et al. Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain. BMC Vet Res. 2022 Aug 6;18(1):303. [Content Brief]

[5]. Kang SJ, et al. Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats. J Orthop Surg Res. 2014 Mar 7;9(1):14. [Content Brief]

[6]. Liu L, et al. Effects of calcium gluconate on lipopolysaccharide-induced acute lung injury in mice. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2931-2935. [Content Brief]

[7]. R Touir, et al. Sodium gluconate as corrosion and scale inhibitor of ordinary steel in simulated cooling water. Corrosion Science Volume 50, Issue 6, June 2008, Pages 1530-1537

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	4.5842 mL	22.9211 mL	45.8421 mL	114.6053 mL
H₂O	5 mM	0.9168 mL	4.5842 mL	9.1684 mL	22.9211 mL
	10 mM	0.4584 mL	2.2921 mL	4.5842 mL	11.4605 mL
	15 mM	0.3056 mL	1.5281 mL	3.0561 mL	7.6404 mL
	20 mM	0.2292 mL	1.1461 mL	2.2921 mL	5.7303 mL
	25 mM	0.1834 mL	0.9168 mL	1.8337 mL	4.5842 mL
	30 mM	0.1528 mL	0.7640 mL	1.5281 mL	3.8202 mL
	40 mM	0.1146 mL	0.5730 mL	1.1461 mL	2.8651 mL
	50 mM	0.0917 mL	0.4584 mL	0.9168 mL	2.2921 mL
	60 mM	0.0764 mL	0.3820 mL	0.7640 mL	1.9101 mL
	80 mM	0.0573 mL	0.2865 mL	0.5730 mL	1.4326 mL
	100 mM	0.0458 mL	0.2292 mL	0.4584 mL	1.1461 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gluconate sodium

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