Cepharadione B
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC50 value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells.
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- CAS. Nr.: 55610-02-1
- Formel: C19H15NO4
- Molecular Weight:321.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | GI50 |
>10 μg/mL
Compound: 1
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Growth inhibition of human BXPC3 cells after 48 hrs by SRB assay
Growth inhibition of human BXPC3 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
| DU-145 | GI50 |
36.1 μg/mL
Compound: 1
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Growth inhibition of human DU145 cells after 48 hrs by SRB assay
Growth inhibition of human DU145 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
| KM-20L2 | GI50 |
>10 μg/mL
Compound: 1
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Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay
Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
| MCF7 | GI50 |
>10 μg/mL
Compound: 1
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Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
| NCI-H460 | GI50 |
>10 μg/mL
Compound: 1
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Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
| SF-268 | GI50 |
22.8 μg/mL
Compound: 1
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Growth inhibition of human SF268 cells after 48 hrs by SRB assay
Growth inhibition of human SF268 cells after 48 hrs by SRB assay
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[PMID: 17624787] |
Chemical Information
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CAS. Nr. 55610-02-1
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Molecular Weight 321.33
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Formel C19H15NO4
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SMILES
O=C1C(N(C)C2=C3C1=CC(OC)=C(OC)C3=C4C(C=CC=C4)=C2)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Mata R, et al. Antimycobacterial compounds from Piper sanctum. J Nat Prod. 2004;67(12):1961-1968. [Content Brief]
[2]. Chou SC, et al. The constituents and their bioactivities of Houttuynia cordata. Chem Pharm Bull (Tokyo). 2009;57(11):1227-1230. [Content Brief]
[3]. Kim SK, et al. Cytotoxic alkaloids from Houttuynia cordata. Arch Pharm Res. 2001;24(6):518-521. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cepharadione B Related Classifications
HY-123898 Related Classifications
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