Cytotoxic alkaloids from Houttuynia cordata

  • Arch Pharm Res. 2001 Dec;24(6):518-21. doi: 10.1007/BF02975156.
S K Kim  1 ,  S Y Ryu ,  J No ,  S U Choi ,  Y S Kim
Affiliations
PMID: 11794526 DOI: 10.1007/BF02975156
Abstract

Six bioactive Alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

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