Dankasterone A
Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the Fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer.
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- CAS. Nr.: 244303-77-3
- Formel: C28H40O3
- Molecular Weight:424.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Fungal Metabolite |
HO-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
25 μM
Compound: 15
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Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
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[PMID: 37676247] |
Dankasterone A (72 h) dose-dependently inhibits viability of PC-3 and 22Rv1 prostate cancer cells with IC50 values of 5.10 μM and 3.41 μM, respectively[1].
Dankasterone A (2.5-10 μM; 48 h) dose-dependently increases HO-1 protein expression in PC-3 and 22Rv1 prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 244303-77-3
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Molecular Weight 424.62
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Formel C28H40O3
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SMILES
C[C@@]12[C@]3(C(CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C)C)=O)[C@@](CC1)([H])[C@@]4(C(C(C3)=O)=CC(CC4)=O)C
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Structure Classification
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Initial Source
endolichenic fungus Pleosporales sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dankasterone A Related Classifications
HY-N17406 Related Classifications
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- Dankasterone A
- 244303-77-3
- Endogenous Metabolite
- Fungal
- Heme Oxygenase (HO)
- Apoptosis
- Reactive Oxygen Species (ROS)
- zebrafish xenograft tumor model
- Heme oxygenase-1 (HO-1)
- apoptosis inducer
- prostate cancer cells
- oxidative stress inducer
- cell proliferation inhibitor
- 22Rv1
- normal prostate epithelial cells
- PC-3
- reactive oxygen species (ROS)
- Inhibitor
- inhibitor
- inhibit