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Art. -Nr.: HY-135945

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Dihydrocoptisine

Dihydrocoptisine is a benzylisoquinoline alkaloid that can be isolated from the methanolic extract of the whole plant of Argemone mexicana L. Dihydrocoptisine can activate XBP1 transcription activity. Dihydrocoptisine can be studied in research on anti-ulcertative colitis.

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CAS. Nr.: 53777-78-9
Formel: C₁₉H₁₅NO₄
Molecular Weight:321.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Dihydrocoptisine Chemical Structure

CAS. Nr.: 53777-78-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI	32.09 % Compound: 2	Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay	[PMID: 25203783]
A549	IC₅₀	>5 μg/mL Compound: 2	Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
Bel-7402	IC₅₀	>5 μg/mL Compound: 2	Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
C-33-A	IC₅₀	>5 μg/mL Compound: 2	Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
HCT-8	IC₅₀	>5 μg/mL Compound: 2	Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]

Chemical Information

CAS. Nr. 53777-78-9
Molecular Weight 321.33
Formel C₁₉H₁₅NO₄
SMILES

O1C=2C=CC=3C=C4C5=CC=6OCOC6C=C5CCN4CC3C2OC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Singh S, et al., A new benzylisoquinoline alkaloid from Argemone mexicana. Nat Prod Res. 2010;24(1):63-7. [Content Brief]

[2]. Li X, et al., Trifluoromethylation of dihydrocoptisines and the effect on structural stability and XBP1-activating activity. J Asian Nat Prod Res. 2022 Apr;24(4):388-396. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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