DDX3X - DEAD-box helicase 3 X-linked Gene

Also Known as DBX; DDX3; HLP2; DDX14; CAP-Rf; MRX102; MRXSSB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1654

About DDX3X

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:41,333,308-41,364,472 (from NCBI)

This gene has 69 transcripts (splice variants), 283 orthologues, 38 paralogues and is associated with 84 phenotypes. Ubiquitous expression in bone marrow (RPKM 90.6), gall bladder (RPKM 60.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

DDX3X Products (4)

mRNA	Protein	Name
NM_001193416.3	NP_001180345.1	ATP-dependent RNA helicase DDX3X isoform 2
NM_001193417.3	NP_001180346.1	ATP-dependent RNA helicase DDX3X isoform 3
NM_001356.5	NP_001347.3	ATP-dependent RNA helicase DDX3X isoform 1
NM_001363819.1	NP_001350748.1	ATP-dependent RNA helicase DDX3X isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	10074132	GOA
enables CTPase activity	IDA IDA: Inferred from direct assay	10074132	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	21589879	GOA
enables DNA helicase activity	IDA IDA: Inferred from direct assay	21589879	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	10074132	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	21589879	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	21589879	GOA
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	22872150	GOA
enables RNA strand annealing activity	IDA IDA: Inferred from direct assay	27546789	GOA
enables eukaryotic initiation factor 4E binding	IDA IDA: Inferred from direct assay	17667941	GOA
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	28842590	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	22872150	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	29062139	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	18596238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10074132	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	23413191	GOA
enables ribonucleoside triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10074132	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	22323517	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23478265	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	16818630	GOA
enables translation initiation factor binding	IDA IDA: Inferred from direct assay	22323517	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in RNA secondary structure unwinding	IDA IDA: Inferred from direct assay	22872150	GOA
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	26235985	GOA
involved in cellular response to arsenic-containing substance	IDA IDA: Inferred from direct assay	21883093	GOA
involved in cellular response to osmotic stress	IDA IDA: Inferred from direct assay	21883093	GOA
involved in cellular response to virus	IDA IDA: Inferred from direct assay	31575075	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	21730191	GOA
involved in cytosolic ribosome assembly	IMP IMP: Inferred from mutant phenotype	22323517	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	18846110	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	18583960	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	18636090	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16301996	GOA
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	28128295	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18846110	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	16818630	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18846110	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	18846110	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21883093	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	27736973	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	17667941	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	17667941	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20837705	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16301996	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23413191	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18628297	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	16301996	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	10074132	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	30341167	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	27980081	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	30341167	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	27980081	GOA
involved in positive regulation of protein acetylation	IMP IMP: Inferred from mutant phenotype	28128295	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	30341167	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23413191	GOA
involved in positive regulation of toll-like receptor 7 signaling pathway	IDA IDA: Inferred from direct assay	30341167	GOA
involved in positive regulation of toll-like receptor 8 signaling pathway	IDA IDA: Inferred from direct assay	30341167	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16818630	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18583960	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	18596238	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	28842590	GOA
involved in positive regulation of translation in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	29062139	GOA
involved in positive regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	20837705	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	23478265	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	20862261	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24965446	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	18636090	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	21883093	GOA
involved in translational initiation	IMP IMP: Inferred from mutant phenotype	26100019	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	28733330	GOA
located in centrosome	IDA IDA: Inferred from direct assay	28842590	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	18636090	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10329544	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	10074132	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	18596238	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	18596238	GOA
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	18628297	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10074132	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	29899501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX3X Protein Structure

DEAD

Helicase_C

0
200
400
600
662 a.a.

Protein Preferred Names	Protein Names
ATP-dependent RNA helicase DDX3X	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

DDX3X Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DDX3X	O00571	NCAPH	Homo sapiens	Q15003	Anti Bait CoIP	21730191
Intra	DDX3X	O00571	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	18596238
Intra	DDX3X	O00571	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	22323517
Intra	DDX3X	O00571	EIF2S1	Homo sapiens	P05198	Cosedimentation	18596238
Intra	DDX3X	O00571	IKBKE	Homo sapiens	Q14164	Anti Bait CoIP	18636090
Intra	DDX3X	O00571	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	18636090
Intra	DDX3X	O00571	EIF3C	Homo sapiens	Q99613	Anti Bait CoIP	22323517
Intra	DDX3X	O00571	EIF3C	Homo sapiens	Q99613	Anti Tag CoIP	22323517
Intra	DDX3X	O00571	EIF3C	Homo sapiens	Q99613	Anti Bait CoIP	18628297
Intra	DDX3X	O00571	EIF3B	Homo sapiens	P55884	Anti Bait CoIP	18628297
Intra	DDX3X	O00571	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	18628297
Intra	DDX3X	O00571	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	DDX3X	O00571	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	DDX3X	O00571	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	DDX3X	O00571	NXF1	Homo sapiens	Q9UBU9	Anti Tag CoIP	18596238
Intra	DDX3X	O00571	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	DDX3X	O00571	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	DDX3X	O00571	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	DDX3X	O00571	EIF4G1	Homo sapiens	Q04637	Pull Down	22872150
Intra	DDX3X	O00571	EIF4G1	Homo sapiens	Q04637	IF	22872150
Intra	DDX3X	O00571	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	22872150
Cross	DDX3X	O00571	Trpm7	Mus musculus	Q923J1	Anti Tag CoIP	24855944
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	18596238
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	IF	21883093
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Confocal	21883093
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	21883093
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Pull Down	22872150
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Pull Down	21883093
Intra	DDX3X	O00571	PABPC1	Homo sapiens	P11940	Confocal	18596238
Intra	DDX3X	O00571	RIGI	Homo sapiens	O95786	Anti Tag CoIP	20127681
Intra	DDX3X	O00571	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	20127681
Intra	DDX3X	O00571	MAVS	Homo sapiens	Q7Z434	Confocal	20127681
Cross	DDX3X	O00571	L	Lymphocytic choriomeningitis virus	P14240	Anti Tag CoIP	29261807
Cross	DDX3X	O00571	tat	Human immunodeficiency virus	P04608	IF	23840900
Cross	DDX3X	O00571	tat	Human immunodeficiency virus	P04608	Anti Bait CoIP	23840900
Cross	DDX3X	O00571	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Confocal	10074132
Cross	DDX3X	O00571	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	NTPase Assay	10074132
Cross	DDX3X	O00571	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Pull Down	20862261
Cross	DDX3X	O00571	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Y2H	10074132
Cross	DDX3X	O00571	polg_hcvjf	Hepatitis C virus	Q99IB8	IF	22616990
Cross	DDX3X	O00571	polg_hcvjf	Hepatitis C virus	Q99IB8	Y2H	22616990
Cross	DDX3X	O00571	OPG044	Vaccinia virus	P68467	Anti Bait CoIP	18636090
Cross	DDX3X	O00571	OPG044	Vaccinia virus	P68467	IF	18636090
Cross	DDX3X	O00571	PB2	Influenza A virus	P03427	SLC	23816991
Cross	DDX3X	O00571	P26664-PRO_0000037517	Hepatitis C virus	P26664-PRO_0000037517	Pull Down	10336476

Cross: Cross-species interaction Intra: Intraspecies interaction

DDX3X Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80642	DDX3 Antibody (YA784)	WB, ICC/IF, IP, ChIP	Human, Rat, Mouse, Monkey
HY-P80642A	DDX3 Antibody (YA784)(PBS only)	WB, ICC/IF, IP, ChIP	Human, Rat, Mouse, Monkey
HY-P83795	DDX3 Antibody (YA3492)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P83795A	DDX3 Antibody (YA3492)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P85604	DDX3 Antibody (YA5296)	WB, IP, ICC/IF	Human, Rat, Mouse, Monkey

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type	MRXSSB Mental Retardation, X-Linked 102, Formerly Mrx102, Formerly Intellectual Developmental Disorder, X-Linked Syndromic, Snijders Blok Type X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome Mrx102
Corpus Callosum, Agenesis Of, With Facial Anomalies And Robin Sequence	Toriello-Carey Syndrome Corpus Callosum Agenesis-Blepharophimosis-Robin Sequence Syndrome Agenesis Of Corpus Callosum With Facial Anomalies And Robin Sequence Corpus Callosum Agenesis Facial Anomalies Robin Sequence
Rare Genetic Intellectual Disability
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay	CHEGDD
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood	Ebv-Positive T-Cell Lymphoproliferative Disorder Of Childhood Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood Systemic Ebv-Positive T-Cell Lymphoma Of Childhood Systemic Ebv+ T-Cell Lymphoma Of Childhood
Endocervical Adenocarcinoma	Endocervical Carcinoma
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Aggressive Nk-Cell Leukemia	Aggressive Nk-Cell Leukaemia Large Granular Lymphocyte Leukemia, Nk-Cell Type Natural Killer Cell Leukaemia Natural Killer Cell Leukemia Aggressive Nk Cell Leukemia Ankl Aggressive Natural Killer Cell Leukemia Ankcl Aggressive Nk-Cell Lymphoma Nk-Cell Lgl Leukemia Nk-Cell Large Granular Lymphocyte Leukemia Abnormality Of The Ankles Aggressive Natural Killer-Cell Leukemia Leukemia, Large Granular Lymphocytic Leukemia, Natural Killer Cell Large Granular Lymphocytic
Adult Medulloblastoma	Adult Brain Medulloblastoma Medulloblastoma, Adult
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations	Severe Congenital Encephalopathy Due To Mecp2 Mutation Severe Neonatal-Onset Encephalopathy With Microcephaly Encephalopathy, Neonatal Severe Neonatal Severe Encephalopathy Due To Mecp2 Mutations Mecp2-Related Severe Neonatal Encephalopathy Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy Severe Neonatal Encephalopathy Due To Mecp2 Mutations ENS-MECP2 Encephalopathy, Neonatal, Severe
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit	Hgbl-Dh/Th High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03646	DDX3X Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17503	Ddx3x Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23960	Ddx3x Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDX3X	RGD	RGD:1564771
Canis familiaris	DDX3X	VGNC	VGNC:54664
Mus musculus	DDX3X	MGD	MGI:103064
Bos taurus	DDX3X	VGNC	VGNC:56526
Others	DDX3X	NCBI