ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

Also Known as ACS1; LACS; FACL1; FACL2; LACS1; LACS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2180

About ACSL1

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,755,595-184,826,594 (from NCBI)

This gene has 16 transcripts (splice variants), 326 orthologues and 12 paralogues. Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues.

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A Ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ACSL1 Products (18)

mRNA Protein Name
NM_001286708.2 NP_001273637.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001286710.2 NP_001273639.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001286711.2 NP_001273640.1 long-chain-fatty-acid--CoA ligase 1 isoform c
NM_001381877.1 NP_001368806.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381878.1 NP_001368807.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381879.1 NP_001368808.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381880.1 NP_001368809.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381881.1 NP_001368810.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381882.1 NP_001368811.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381883.1 NP_001368812.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381884.1 NP_001368813.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381885.1 NP_001368814.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381886.1 NP_001368815.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381887.1 NP_001368816.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381888.1 NP_001368817.1 long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381889.1 NP_001368818.1 long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381890.1 NP_001368819.1 long-chain-fatty-acid--CoA ligase 1 isoform f
NM_001995.5 NP_001986.2 long-chain-fatty-acid--CoA ligase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
21242590 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in fatty acid transport IMP
IMP: Inferred from mutant phenotype
32521232 GOA
involved in lipid biosynthetic process IDA
IDA: Inferred from direct assay
21242590 GOA
involved in lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
25592151 GOA
involved in long-chain fatty acid import into cell IDA
IDA: Inferred from direct assay
22022213 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
22022213 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24269233 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
22022213 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSL1 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (116 - 562)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 1

  • LACS 1

Related Diseases

Diseases Alias
Retinal Dystrophy With Leukodystrophy

  • RDLKD

  • Acbd5 Deficiency

  • Dystrophy, Retinal, With Leukodystrophy
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N0723 Neomangiferin 99.80% Unkown
HY-186096 LP-856866 99.92% Unkown
HY-186095 LP-911888 Inhibitor 99.83% Unkown
HY-RS00200 ACSL1 Human Pre-designed siRNA Set A / Unkown
HY-RS16255 Acsl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS24003 Acsl1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACSL1 VGNC VGNC:69564
Bos taurus ACSL1 VGNC VGNC:25564
Canis familiaris ACSL1 VGNC VGNC:37532
Felis catus ACSL1 VGNC VGNC:59534
Mus musculus ACSL1 MGD MGI:102797
Rattus norvegicus ACSL1 RGD RGD:2015
Others ACSL1 NCBI