Arpc2 - actin related protein 2/3 complex, subunit 2 Gene

Also Known as p34Arc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301511

About Arpc2

Primary_assembly 9: 75,820,770-75,851,471 forward strand.mRatBN7.2:CM026982.1

This gene has 5 transcripts (splice variants), 241 orthologues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 125.8), Thymus (RPKM 929.) and 9 other tissues.

Summary

Enables several functions, including AP-1 adaptor complex binding activity; ATPase binding activity; and Arp2/3 complex binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to rapamycin; and positive regulation of cellular component organization. Located in several cellular components, including actin cytoskeleton; dendrite; and distal axon. Part of filamentous actin. Biomarker of silicosis. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Arpc2 Products (1)

mRNA Protein Name
NM_001106919.1 NP_001100389.1 actin-related protein 2月3日 complex subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables AP-1 adaptor complex binding IDA
IDA: Inferred from direct assay
22689987 RGD
enables ATPase binding IPI
IPI: Inferred from physical interaction
18297063 RGD
enables Arp2/3 complex binding IDA
IDA: Inferred from direct assay
22689987 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
18297063 RGD
enables kinesin binding IDA
IDA: Inferred from direct assay
22689987 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17456547 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17350576 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
15252126 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
24152438 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
10797548 RGD
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
22619279 RGD
involved in cellular response to rapamycin IDA
IDA: Inferred from direct assay
11598004 RGD
involved in positive regulation of barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
15252126 RGD
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
15252126 RGD
involved in positive regulation of podosome assembly IMP
IMP: Inferred from mutant phenotype
17224451 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
20739464 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
24152438 RGD
involved in protein kinase C signaling IDA
IDA: Inferred from direct assay
16027158 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20739464 RGD
involved in response to silicon dioxide IEP
IEP: Inferred from expression pattern
18685790 RGD
Cellular Component GO Annotation Evidence Verweise Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
18509026 RGD
located in actin filament branch point IDA
IDA: Inferred from direct assay
18256280 RGD
located in apical dendrite IDA
IDA: Inferred from direct assay
18509026 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
18509026 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
16027158 RGD
located in cell surface IDA
IDA: Inferred from direct assay
11598004 RGD
located in concave side of sperm head IDA
IDA: Inferred from direct assay
23403943 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
18509026 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18509026 RGD
part of filamentous actin IDA
IDA: Inferred from direct assay
10797548 RGD
located in growth cone IDA
IDA: Inferred from direct assay
10797548 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
15684033 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
18509026 RGD
located in peripheral region of growth cone IDA
IDA: Inferred from direct assay
18256280 RGD
located in podosome core IDA
IDA: Inferred from direct assay
17224451 RGD
located in podosome ring IDA
IDA: Inferred from direct assay
17224451 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
18509026 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
17224451 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
14617808 RGD
located in ventral surface of cell IDA
IDA: Inferred from direct assay
11598004 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Arpc2 Protein Structure

P34-Arc

P34-Arc: pfam04045 (56 - 283)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 2

  • arp2/3 complex 34 kDa subunit

  • p34-ARC

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-114657A Benproperine phosphate Inhibitor 99.93% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01015 ARPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01016 Arpc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01017 Arpc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arpc2 NCBI NCBI:10109