PLA2G12B - phospholipase A2 group XIIB Gene

Also Known as GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84647

About PLA2G12B

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,934,762-72,954,806 (from NCBI)

This gene has 1 transcript (splice variant), 271 orthologues and 1 paralogue. Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues.

Summary

The protein encoded by this gene belongs to the Phospholipase A2 (PLA2) group of Enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

PLA2G12B Products (3)

mRNA Protein Name
NM_001318124.2 NP_001305053.1 group XIIB secretory phospholipase A2-like protein isoform b precursor
NM_001318125.2 NP_001305054.1 group XIIB secretory phospholipase A2-like protein isoform c
NM_032562.5 NP_115951.2 group XIIB secretory phospholipase A2-like protein isoform a precursor

PLA2G12B Protein Structure

PLA2G12

PLA2G12: Group XII secretory phospholipase A2 precursor (PLA2G12) (14 - 195)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

group XIIB secretory phospholipase A2-like protein

  • group XIII secreted phospholipase A2

Related Diseases

Diseases Alias
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Spastic Paraplegia 39, Autosomal Recessive

  • SPG39

  • Ntemnd

  • Hereditary Spastic Paraplegia 39

  • Nte-Related Motor Neuron Disorder

  • Autosomal Recessive Spastic Paraplegia Type 39

  • Spastic Paraplegia Due To Neuropathy Target Esterase Mutation

  • Spastic Paraplegia Due To Nte Mutation

  • Spastic Paraplegia 39

  • Autosomal Recessive Spastic Paraplegia 39

  • Nte Related Motor Neuron Disorder

  • Paraplegia, Spastic, Type 39
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10618 PLA2G12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19558 Pla2g12b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26054 Pla2g12b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G12B RGD RGD:1588484
Bos taurus PLA2G12B VGNC VGNC:32955
Macaca mulatta PLA2G12B VGNC VGNC:76059
Mus musculus PLA2G12B MGD MGI:1917086
Canis familiaris PLA2G12B VGNC VGNC:44620
Others PLA2G12B NCBI