PRDX6 - peroxiredoxin 6 Gene

Also Known as PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9588

About PRDX6

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,477,335-173,488,815 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

PRDX6 Products (1)

mRNA	Protein	Name
NM_004905.3	NP_004896.1	peroxiredoxin-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	26830860	GOA
enables calcium-independent phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	10893423	GOA
enables glutathione peroxidase activity	IMP IMP: Inferred from mutant phenotype	10893423	GOA
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	9587003	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	26830860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16186110	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular oxidant detoxification	IMP IMP: Inferred from mutant phenotype	10893423	GOA
involved in glycerophospholipid catabolic process	IMP IMP: Inferred from mutant phenotype	10893423	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IGI IGI: Inferred from genetic interaction	16186110	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	10893423	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16186110	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX6 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
200
224 a.a.

Protein Preferred Names	Protein Names
peroxiredoxin-6	1-Cys PRX

PRDX6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32814053
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Y2H Pooling	32814053
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32814053
Intra	PRDX6	P30041	PCNA	Homo sapiens	P12004	Far-WB	20849852
Intra	PRDX6	P30041	PCNA	Homo sapiens	P12004	BiFC	26030842
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Y2H Prey Pooling	32296183
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Validated Y2H	32296183
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Y2H Array	32296183
Intra	PRDX6	P30041	TERF1	Homo sapiens	P54274	Pull Down	21044950
Cross	PRDX6	P30041	P29991-PRO_0000308465	Dengue virus type 2	P29991-PRO_0000308465	Y2H	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX6 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71145	PRDX6 Protein, Human (His)	P30041 (M1-P224)	≥ 95%, as determined by reducing SDS-PAGE.

PRDX6 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83409	Peroxiredoxin 6 Antibody (YA3154)	WB, IP	Human
HY-P83409A	Peroxiredoxin 6 Antibody (YA3154)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Gnathomiasis	Gnathostomiasis Infectious Disease By Gnathostoma Gnathostomosis Wandering Swelling
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Diabetic Cataract	Cataract - Diabetic
Small Intestine Leiomyosarcoma	Leiomyosarcoma Of The Small Bowel Smooth Muscle Connective Tissue Tumor Leiomyosarcoma Of Small Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-115062	MJ33 lithium salt	Inhibitor	99.0%	Unkown
HY-129944A	MJ33-OH lithium	Inhibitor	≥90.0%	Unkown
HY-RS11078	PRDX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-129944	MJ33-OH	Inhibitor	/	Unkown
HY-136271	MJ33	Inhibitor	/	Unkown
HY-RS11079	PRDX6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17470	Prdx6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17919	Prdx5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23928	Prdx6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRDX6	VGNC	VGNC:76267
Felis catus	PRDX6	VGNC	VGNC:107925
Bos taurus	PRDX6	VGNC	VGNC:33304
Mus musculus	PRDX6	MGD	MGI:894320
Canis familiaris	PRDX6	VGNC	VGNC:44953
Rattus norvegicus	PRDX6	RGD	RGD:71005
Others	PRDX6	NCBI