Nav1.8-IN-7
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2761181-58-0
- Formel: C22H18ClF4N3O5
- Molecular Weight:515.84
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Nav1.8-IN-9 (Example 116; 1 μM) shows inhibitions of 1.2％, 3.7％, <1％, <1％, 2.6％, <1％ for Nav1.1, Nav1.3, Nav1.4, Nav1.5, Nav1.6, and Nav1.7, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
| PO (100 mg/kg) | |
| Cmax (ng/mL) | 2566 |
| AUC0-24 (ng/mL∗h) | 42454 |
| t1/2 (h) | 8.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2761181-58-0
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Molecular Weight 515.84
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Formel C22H18ClF4N3O5
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SMILES
OC[C@@H](O)COC1=CC(NC(C(C=C(C(C(F)(F)F)=C2)Cl)=C2OC3=C(C=C(C=C3)F)C)=O)=CN=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vivo:
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Nav1.8-IN-7 Related Classifications
HY-160588 Related Classifications
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