1. Neuronal Signaling
  2. Cholinesterase (ChE) Amyloid-β
  3. Aβ1–42 aggregation inhibitor 1

Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC50 value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease.

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Aβ1–42 aggregation inhibitor 1 Chemical Structure

Aβ1–42 aggregation inhibitor 1 Chemical Structure

CAS No. : 2439107-75-0

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Description

Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC50 value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease[1].

IC50 & Target

IC50: 2.64 μM (AChE), 1.29 μM (BuChE)[1].

In Vitro

Aβ1-42 aggregation inhibitor 1 (compound 50) (25 μM, 30 min) can selectively form ligand-Cu 2+ complexes with Cu2+[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.66

Formula

C29H32N4S

CAS No.
SMILES

CCN1C2=CC=C(/C=C/C3=CC=C(C=C3)NC(NCCN4CCCC4)=S)C=C2C5=CC=CC=C51

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Aβ1–42 aggregation inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aβ1–42 aggregation inhibitor 1
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HY-150003
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