Batracylin (Synonyms: NSC 320846; BAY-H 2049)

Name: Batracylin
Brand: MedChemExpress
SKU: HY-119892
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Art. -Nr.: HY-119892: Data Sheet Handling Instructions
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Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks.

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Batracylin Chemische Struktur

CAS. Nr. : 67199-66-0

Größe	Verfügbarkeit	Menge
1 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
25 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
500 mg	Angebot einholen 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
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5 g	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Topoisomerase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Topoisomerase Topo I Topo II DNA gyrase

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	46.3 μM Compound: BAT; Batracylin	Cytotoxicity against human A549 cells after 120 hrs by MTT assay Cytotoxicity against human A549 cells after 120 hrs by MTT assay	[PMID: 26520842]
CCRF-CEM	IC₅₀	14 μM Compound: 1	Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells	[PMID: 7932571]
HCT-116	IC₅₀	88.7 μM Compound: BAT; Batracylin	Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay	[PMID: 26520842]
HL-60	IC₅₀	66.6 μM Compound: BAT; Batracylin	Cytotoxicity against human HL60 cells after 120 hrs by MTT assay Cytotoxicity against human HL60 cells after 120 hrs by MTT assay	[PMID: 26520842]
HT-29	IC₅₀	64.3 μM Compound: BAT; Batracylin	Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay	[PMID: 26520842]
L1210	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay	[PMID: 26520842]
LNCaP	IC₅₀	90.2 μM Compound: BAT; Batracylin	Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay	[PMID: 26520842]
MCF7	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay	[PMID: 26520842]
NIH3T3	IC₅₀	69.9 μM Compound: BAT; Batracylin	Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay	[PMID: 26520842]
P388	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay	[PMID: 26520842]

In Vitro

Batracylin (0-300 µM; 6 h) shows cytotoxicity with an IC₅₀ value of 10.02 µM for HT29 cells^[1].
Batracylin (100, 300 µM; 3 h) induces protein-linked DNA breaks consistent with topoisomerase targeting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

249.27

Formel

C₁₅H₁₁N₃O

CAS. Nr.

67199-66-0

SMILES

O=C1C2=C(C=CC=C2)C3=NC4=C(CN31)C=C(C=C4)N

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9. [Content Brief]

Batracylin Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batracylin67199-66-0NSC 320846 BAY-H 2049NSC320846NSC-320846TopoisomeraseHT29 cellsDNA breaksγ-H2AXcytotoxicityInhibitorinhibitorinhibit

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Batracylin (Synonyms: NSC 320846; BAY-H 2049)

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Batracylin Related Antibodies

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Topoisomerase Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

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Batracylin Related Antibodies

Batracylin Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

Ihre kürzlich angesehenen Produkte:

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