BChE/p38-α MAPK-IN-2
BChE/p38-α MAPK-IN-2 is a BChE and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC50 of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC50 of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease.
For research use only. We do not sell to patients.
- Formula: C27H33N5O4
- Molecular Weight:491.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hBCHE 5.1 nM (IC50) |
hAChE 3.1 μM (IC50) |
BChE/p38-α MAPK-IN-2 (10-50 μM) shows no obvious cytotoxicity in BV2 microglial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino Swiss (CD-1) mice with Scopolamine-induced amnesia[1]
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Dosage:5 and 10 mg/kg
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Administration:Intraperitoneally injection, 60 mins before tests
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Result:Prolonged step-through latency in the passive avoidance task.
Enhanced the preference for novel objects in the novel object recognition task.
Chemical Information
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Molecular Weight 491.58
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Formula C27H33N5O4
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SMILES
CC(NCC(NCC1=CC=CC(N2N=C(C=C2OC(N(CC3=CC=CC=C3)C)=O)C(C)(C)C)=C1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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