BChE/p38-α MAPK-IN-2
BChE/p38-α MAPK-IN-2 is a BChE and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC50 of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC50 of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H33N5O4
- 分子量:491.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hBCHE 5.1 nM (IC50) |
hAChE 3.1 μM (IC50) |
BChE/p38-α MAPK-IN-2 (10-50 μM) shows no obvious cytotoxicity in BV2 microglial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino Swiss (CD-1) mice with Scopolamine-induced amnesia[1]
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Dosage:5 and 10 mg/kg
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Administration:Intraperitoneally injection, 60 mins before tests
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Result:Prolonged step-through latency in the passive avoidance task.
Enhanced the preference for novel objects in the novel object recognition task.
化学情報
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分子量 491.58
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分子式 C27H33N5O4
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SMILES
CC(NCC(NCC1=CC=CC(N2N=C(C=C2OC(N(CC3=CC=CC=C3)C)=O)C(C)(C)C)=C1)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE/p38-α MAPK-IN-2 関連分類
HY-178433 関連分類
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