Ceramide synthase 4

Definition:

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.

References:

[1]. Rotem Tidhar, et al. Eleven residues determine the acyl chain specificity of ceramide synthases. J Biol Chem. 2018 Jun 22;293(25):9912-9921. [Content Brief]

[2]. Keisuke Jojima, et al. Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3. FASEB J. 2020 Feb;34(2):3318-3335. [Content Brief]

[3]. Sujoy Lahiri, et al. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94. [Content Brief]

[4]. Takayuki Sassa, et al. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. J Biol Chem. 2016 Apr 1;291(14):7477-87. [Content Brief]

[5]. Sarah Brice Russo, et al. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. J Biol Chem. 2013 May 10;288(19):13397-409. [Content Brief]

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