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Interleukin-3

Definition:

Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.

References:

[1]. Li Hong, et al. Interleukin 3-induced GITR promotes the activation of human basophils. Cytokine. 2020 Dec;136:155268. [Content Brief]

[2]. S C Guba, et al. Regulation of interleukin 3 gene induction in normal human T cells. J Clin Invest. 1989 Dec;84(6):1701-6. [Content Brief]

[3]. Sophie E Broughton, et al. A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nat Commun. 2018 Jan 26;9(1):386. [Content Brief]

[4]. Camila López, et al. Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J Cell Biochem. 2017 Jun;118(6):1330-1340. [Content Brief]

[5]. Y Okayama, et al. Comparison of mechanisms of IL-3 induced histamine release and IL-3 priming effect on human basophils. Clin Exp Allergy. 1993 Nov;23(11):901-10. [Content Brief]

[6]. Xiong-jian Luo, et al. The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors. PLoS One. 2012;7(11):e50375. [Content Brief]

[7]. Shruti M Khapli, et al. IL-3 acts directly on osteoclast precursors and irreversibly inhibits receptor activator of NF-kappa B ligand-induced osteoclast differentiation by diverting the cells to macrophage lineage. J Immunol. 2003 Jul 1;171(1):142-51. [Content Brief]

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