BRD3/BRD4-L ligand-2
BRD3/BRD4-L ligand-2 is a BRD3/BRD4-L ligand. BRD3/BRD4-L ligand-2 serves as a ligand for the target protein in the design and development of PROTAC BRD3/BRD4-L degraders, such as PROTAC BRD3/BRD4-L degrader-2 (HY-149948). BRD3/BRD4-L ligand-2 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3075063-28-1
- Formula: C26H26ClN5
- Molecular Weight:443.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
|
BRD3 |
BRD4-L |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | IC50 |
3786 nM
Compound: 30; GXE148
|
Antiproliferative activity against human MM1.S cells assessed as cell growth inhibition measured after 4 days by CellTitre-Glo assay
Antiproliferative activity against human MM1.S cells assessed as cell growth inhibition measured after 4 days by CellTitre-Glo assay
|
[PMID: 37084596] |
| MV4-11 | IC50 |
1224 nM
Compound: 30; GXE148
|
Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured after 3 days by CellTitre-Glo assay
Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured after 3 days by CellTitre-Glo assay
|
[PMID: 37084596] |
Chemical Information
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CAS No. 3075063-28-1
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Molecular Weight 443.97
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Formula C26H26ClN5
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SMILES
CC1=NN=C2CCC(C3=C(N12)C=CC(C4=CC=C(C=C4)CNC)=C3)NC5=CC=C(C=C5)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)