CA IX-IN-1 

CA IX-IN-1 (compound 12g) is an effective and selective inhibitor of hCA IX with IC₅₀ value of 7 nM. CA IX-IN-1 exhibits antitumor activity^[1].

CA IX-IN-1 (compound 12g) displays effective inhibition against hCA I, hCA II and hCA IX with IC₅₀ values of 4, 0.018, 0.007 μM, respectively^[1].
CA IX-IN-1 (compound 12g) (0.1 μM, 72 hours; HT-29 and MDA-MB-231 cells) exerts the potent antitumor activities against human cancer cell lines^[1].
CA IX-IN-1 (compound 12g) (0-1 mM, 48 hours; HT-29 and MDA-MB-231 cells) induces highly expression level and enzyme activity of HCA IX in tumor cells with enhance the acidification of extracellular pH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

430.43

C₁₆H₂₂N₄O₈S

CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CN2C=C(N=N2)COC3=CC=CC(S(N)(=O)=O)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hao S, et al. Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents. Bioorg Chem. 2020 Nov;104:104237.  [Content Brief]