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Tonlamarsen

(Synonyms: ION-904)

Tonlamarsen (ION-904) is a GalNAc-conjugated antisense oligonucleotide and Angiotensinogen synthesis inhibitor. Tonlamarsen specifically reduces the production of Angiotensinogen in the liver and plasma, and exhibits extremely low activity in the kidneys. Tonlamarsen can be used in research related to hypertension and heart failure.

For research use only. We do not sell to patients.

  • CAS No.: 2589926-20-3
  • Formula: C241H349N65O12P16S12
  • Molecular Weight:7021.13
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Tonlamarsen Chemical Structure
    Tonlamarsen Chemical Structure
CAS No.: 2589926-20-3
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Angiotensin Receptor Isoforms

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  • Tonlamarsen Chemical Structure
    Tonlamarsen Chemical Structure DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]
    1/16
  • DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]