XL-281
XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 870603-16-0
- Formula: C24H19ClN4O4
- Molecular Weight:462.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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C-Raf 2.6 nM (IC50) |
B-Raf 4.5 nM (IC50) |
B-RafV600E 6 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-MEL19 | IC50 |
200 nM
Compound: 8; XL281; BMS-908662
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Cytotoxicity against human SK-MEL-19 cells harboring BRAF mutant after 3 days
Cytotoxicity against human SK-MEL-19 cells harboring BRAF mutant after 3 days
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[PMID: 29461827] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 870603-16-0
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Molecular Weight 462.89
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Formula C24H19ClN4O4
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SMILES
O=C(OC)NC1=NC2=CC=C(C3(O)N(C4=CC(Cl)=CC=C4C)C(C5=C3C=CC=C5)=O)C=C2N1
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Synonyms
BMS-908662
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XL-281 Related Classifications
HY-19343 Related Classifications
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