AChE/BChE-IN-12
AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research.
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- Formule: C23H21N3O6
- Masse moléculaire:435.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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EeAChE 2.57 ± 0.3 μM (IC50) |
eqBCHE 3.26 ± 0.1 μM (IC50) |
BACE1 10.65 ± 0. μM (IC50) |
In Vitro
Chemical Information
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Masse moléculaire 435.43
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Formule C23H21N3O6
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SMILES
COC1=CC(CN2C=C(N=N2)COC3=C(C4=C(C=C3)C=CC(O4)=O)C(C)=O)=CC(OC)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-12 Related Classifications
HY-149211 Related Classifications
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