Anti-inflammatory agent 78
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line.
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- Formule: C19H14ClNO4
- Masse moléculaire:355.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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COX-1 |
COX-2 |
In Vitro
Anti-inflammatory agent 78 (compound L-37) has a high tumor cell growth inhibitory ability at 10 μM along with a significant effect on the growth of RAW 264.7 cells[1].
Anti-inflammatory agent 78 (1-10 μM, 24 h) inhibits LPS-induced PGE2 synthesis in RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells
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Concentration:1, 5, 10 μM
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Incubation Time:24 h
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Result:Inhibited LPS-induced PGE2 synthesis in a dosedependent manner. Inhibited the PGF1 production as well as the expression of COX-1, but displayed weak inhibition activity towards the Leukotrienes (LT) and Thromboxane-B2 (TXB-2) production.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (xylene-induced mice ear edema model)[1]
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Dosage:100 mg/kg
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Administration:IP
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Result:Exhibited a dose-dependent anti-inflammatory effect in vivo. L-37 has a slightly weaker inhibitory activity than celecoxib (HY-14398) in animal models, it also shows good activity and a nearly 78.14% inhibition rate at the dosage of 50 mg/kg.
Chemical Information
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Masse moléculaire 355.77
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Formule C19H14ClNO4
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SMILES
OC(C1=CC=C(Cl)C=C1N2CC3=CC=CC=C3)(C#CC(OC)=O)C2=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 78 Related Classifications
HY-162425 Related Classifications
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