Clausenidin
Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 28384-44-3
- Formule: C19H20O5
- Masse moléculaire:328.36
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Caspase
MoreVoir tous les produits spécifiques à Isoform VEGFR
More
Activité biologique
|
Caspase 3 |
Caspase-8 |
Caspase-9 |
Chemical Information
-
CAS No. 28384-44-3
-
Masse moléculaire 328.36
-
Formule C19H20O5
-
SMILES
O=C1OC2=C(C(O)=C3C(CC(C)(C)OC3=C2C(C)(C)C=C)=O)C=C1
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sunthitikawinsakul A, et al. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Planta Med. 2003 Feb;69(2):155-7. [Content Brief]
[2]. Waziri PM, et al. Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. J Ethnopharmacol. 2016 Dec 24;194:549-558. [Content Brief]
[3]. Waziri PM, et al. Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells. Asian Pac J Cancer Prev. 2018 Apr 25;19(4):917-922. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clausenidin Related Classifications
HY-N16771 Related Classifications
Powered by Bioz