Desmethyl etoricoxib
Based on 1 Customer Validation
Desmethyl etoricoxib (example 21) is a selective COX-2 inhibitor with an IC50 of 1 μM in whole blood. Desmethyl etoricoxib inhibits COX-1 with an IC50 of 16 μM in U937 cells. Desmethyl etoricoxib has anti-inflammatory effects.
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- Pureté : 99.64%
- CAS No.: 202409-31-2
- Formule: C17H13ClN2O2S
- Masse moléculaire:344.82
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
COX-2 1 μM (IC50) |
COX-1 16 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.034 μM
Compound: 18
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In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
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[PMID: 9873621] |
| U-937 | IC50 |
19 μM
Compound: 18
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Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidonic acid conc.
Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidonic acid conc.
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[PMID: 9873621] |
Chemical Information
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CAS No. 202409-31-2
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Appearance Solid
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Masse moléculaire 344.82
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Formule C17H13ClN2O2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=CN=C3)C=C1)(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (362.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9001 mL | 14.5003 mL | 29.0006 mL | 72.5016 mL |
| 5 mM | 0.5800 mL | 2.9001 mL | 5.8001 mL | 14.5003 mL | |
| 10 mM | 0.2900 mL | 1.4500 mL | 2.9001 mL | 7.2502 mL | |
| 15 mM | 0.1933 mL | 0.9667 mL | 1.9334 mL | 4.8334 mL | |
| 20 mM | 0.1450 mL | 0.7250 mL | 1.4500 mL | 3.6251 mL | |
| 25 mM | 0.1160 mL | 0.5800 mL | 1.1600 mL | 2.9001 mL | |
| 30 mM | 0.0967 mL | 0.4833 mL | 0.9667 mL | 2.4167 mL | |
| 40 mM | 0.0725 mL | 0.3625 mL | 0.7250 mL | 1.8125 mL | |
| 50 mM | 0.0580 mL | 0.2900 mL | 0.5800 mL | 1.4500 mL | |
| 60 mM | 0.0483 mL | 0.2417 mL | 0.4833 mL | 1.2084 mL | |
| 80 mM | 0.0363 mL | 0.1813 mL | 0.3625 mL | 0.9063 mL | |
| 100 mM | 0.0290 mL | 0.1450 mL | 0.2900 mL | 0.7250 mL |
Desmethyl etoricoxib Related Classifications
HY-138101 Related Classifications
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