DNH28
DNH28 is a potent NF-κB and MAPK inhibitor with an IC50 of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and Cleaved-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C23H24ClF3N2O
- Masse moléculaire:436.90
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Caspase
More
Activité biologique
|
Caspase 3 |
Bax |
Bcl-2 |
NF-κB |
DNH28 (Compound 28) exhibits lower toxicity toward THLE-3 cells (IC50 = 18.16 μM)[1].
DNH28 (0.46-1.84 μM, 24 h) inhibits HepG2 cells proliferation by inducing apoptosis and dose-dependently inhibits HepG2 cells in the G2/M phase[1].
DNH28 (0.46-1.84 μM, 24 h) inhibits HepG2 cell migration dose-dependently, and it completely inhibits the migration ability at a concentration of 1.84 μM[1].
DNH28 (1.84 μM, 24 h) effectively inhibits the nuclear translocation of p65 induced by TNF-α[1].
DNH28 (0.46-1.84 μM, 24 h) exerts anti-HCC effects by inhibiting the activation of NF-κB and MAPK signaling pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:0.46, 0.92 and 1.84 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis dose-dependently.
Reached 45.90% of apoptotic cells at 1.84 μM (compared with 14.57% in the control group).
-
Cell Line:HepG2 cells
-
Concentration:0.46, 0.92 and 1.84 μM
-
Incubation Time:24 h
-
Result:Reached 76.22% G2/M phase ratio at 1.84 μM.
-
Cell Line:HepG2 cells
-
Concentration:0.46, 0.92 and 1.84 μM
-
Incubation Time:24 h
-
Result:Partially suppressed cell migration, whereas at 1.84 μM, the scratch width remained unchanged.
-
Cell Line:HepG2 cells
-
Concentration:0.46, 0.92 and 1.84 μM
-
Incubation Time:24 h
-
Result:Increased the expression of pro-apoptotic mRNA levels BAX and C-caspase-3.
Reduced the expression of the anti-apoptotic mRNA levels of BCL-2.
-
Cell Line:HepG2 cells
-
Concentration:0.46, 0.92 and 1.84 μM
-
Incubation Time:24 h
-
Result:Exhibited dose-dependent inhibition of the phosphorylation of p65, IκB-α, p38 and ERK.
Significantly down-regulated the activation of the NF-κB and MAPK signaling pathways
Chemical Information
-
Masse moléculaire 436.90
-
Formule C23H24ClF3N2O
-
SMILES
CCN1CCN(C2=CC(CC/C(C3=O)=C\C4=CC=C(F)C(F)=C4F)=C3C=C2)CC1.Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNH28 Related Classifications
HY-175037 Related Classifications
Powered by Bioz